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THE PHARMA REVIEW (NOVEMBER - DECEMBER 2011)

Immobilised CAL B – An Ace Bio Catalyst

Sandeep Bijamwar

Abstract: Nature is a perfect synthetic chemist. Plants, for example, have access only to air,soil and energy from sun, and they produce countless amounts of compounds with enormous complexity. From nature we may get hints for developing cost effective and sustainable methods to prepare biologically active compounds. Enzymes are biocatalyst responsible for chemical transformation in nature. According to the types of reactions they catalysed. Since Enzymes posses valuable features, such as Chemoselectvity, regioselectivity and stereoslectivity, integrating enzymes in to organic synthesises supposed to full fill the increasing demands for preparing compounds in selective matter. Immobilised CAL B Lipase (Candida antartica lipase B) is very well characterised biocatalyst and its highly diversified used. Immobilised CAL B catalysing a great number of different organic reactions including many that have been scaled up to commercial scale.

 
Applications The chemical and pharmaceutical industries have been somewhat slow to embrace the area of biocatalysts due to the chemist or R&D familiarity with the current chemical synthesis processes and the cost involved in the conversion. All this is changing rapidly,however,with Enzymes providing a more cost effective, safer and environmentally-friendly alternative.

 
Attractive features of the IMMOBILISED CAL B Lipase include its versality,regio-,chemo- and enatio- selectivity which are paramount importance across the Pharma and chemical industry.

 
One of the main reason of its success was the specificity of the IMMOBILISED CAL B, there by minimising the purification cost. In fine chemical companies CALB reactions that generate chiral centres as they convert prochiral substrate into single enantiomer product for the synthesis of amino acids and other compounds, offering 100% theoretical yield.Many chemical and Pharma companies are changing their attitude due to the promising results of CALB coupled with chemocatylytic reactions.

 

 

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