Study and Evaluation of Various PVA - Based Film Coating Systems of Instacoat

Swapnali Bhaskar1, Rajani Athawale1, Chetan Rajsharad2 & Noorjahan Aibani2

Abstract: Tablet coating is one of the oldest pharmaceutical processes. The article describes the recent experience of authors in developing & evaluating of aqueous and organic solvents film coating systems. It covers studies on latest material developed by Ideal Cures available to coat tablets and experimental techniques to assess various properties of both free and applied films, including water vapor and oxygen permeability, thermal, mechanical, and adhesive characteristics. It also gives a detailed account of overall behavior of all four coating systems now available from Ideal Cures. Coating systems undertaken for study developed by Ideal Cures are PVA based, identified as – IC 1, IC 2, IC 3 and IC 4.

Introduction: Tablets are by far the most popular dosage form when administering drugs to patients. The film coating became so acceptable that coated tablets which accounted only 10% of all tablets produced in 1960 rose to about 90% of all tablets in the market today. Tablet film coating is of two types, aqueous (solvent – water based) and non-aqueous (organic solvent based). The thickness of film coating is usually between 20 and 100 μm. Yet as use of organic solvent based coatings grew concern environmental pollution & operator safety prompted new laws to address both concerns. This new regulatory backdrop led the industry to switch from organic solvent based coating to aqueous coatings.
High quality aqueous film coating has been used extensively in the pharmaceutical industry, e.g. for the application of non-functional or functional coats (aesthetic, protective or rate controlling polymer films) and for the deposition of API’s onto nonpareils (multi-particulate dosage forms).
Today there are several automated technologies available for the coating the tablets, pellets, pills, granules and powder. This is due to the continuous process development, research work towards better patient compliance, cost saving, time saving and long term stability of the drug. Coating is not limited to pharmaceutical industries but also includes various other medicine systems like Unnani & Siddha, Ayurvedic formulations, Nutraceuticals and Agrochemicals.
The components are purchased separately, combined at the time of use or purchased together as preformulated coating systems. Buying them as a system or ready-mix reduces number of ingredients in your inventory and thus eases the burden of preparing some complicated systems.
The pharma industry has been employing synthetic polymer film forming material as specialized coating for drug particle and dosage forms and hence evaluation of coating with respect to different physical & chemical properties have attained prime importance.



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