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THE PHARMA REVIEW (NOVEMBER DECEMBER 2012)

Dengue Prevalence and Management

Vidya Sagar.R.A1, Anoop Paruchuri1, Zahed1, Mohanta G.P1, & Dr.S.Selvamuthu Kumaran2

Introduction:
 
Dengue is a mosquito borne viral disease that occurs most rapidly and widely. It is estimated that 50 million infections occur annually. The incidence of dengue has multiplied many times over last five decades at an alarming rate. In endemic areas, waves of infection occur in epidemics with thousands of individuals affected, creating huge burden on the limited resources of countries health care system. As the disease is systemic and dynamic, it has wide spectrum that includes severe and non-severe clinical manifestations. There are three phases that occur after the incubation period of 4-10 days i.e. febrile, critical and recovery. Immediately after evaluating history, physical examination and/or full blood count and hematocrit, clinicians should be able to determine whether the disease is dengue and in which phase it is. Paracetmol is preferred when patient is uncomfortable and in high fever, dosing should not be less than six hours. Non-steroidal anti-inflammatory agents are contraindicated as those drugs i.e. acetylsalicylic acid, ibuprofen may aggravate gastritis and internal bleeding. Avoiding human vector contact and controlling the mosquito vectors is the only method for preventing the transmission of dengue virus. Several experimentations in developing dengue vaccines are under progress around worldwide; they are not likely to be available for public at least in next 5 years. Developing new vaccine is a crucial and critical step as it should immunize against all four serotypes effectively.

 

 

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