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THE PHARMA REVIEW (NOVEMBER DECEMBER 2012)

Natural Excipients A Biocompatible Drug Delivery Carriers - Overview

Raghupatruni Jhansi Laxmi1, R. Karthikeyan2, P. Srinivasa Babu1, & R.V.V. Narendra Babu3

Introduction:
 
In recent years, plant derived polymers have evoked tremendous because of their varied pharmaceutical applications such as diluents, binder, disintegrant in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels and bases in suppository. They are also useful in cosmetics, textiles, paints and paper-making1. These gums and mucilage have advantages over synthetic as they are chemically inert, cheap and easily available, non-toxic, biodegradable, soothing action and non-irritant in nature. Gums are formed upon injury of the plant or owing to the unfavorable conditions such as drought, by a breakdown of cell walls (extracellular) whereas mucilages are normal physiological products of metabolism formed within the cell (intracellular) and are produced without injury to the plants. Hence gums are considered as pathological products whereas mucilages are physiological products. Gums swell in water to form sticky, colloidal dispersions whereas mucilage forms slippery, aqueous colloidal dispersions2. Mucilage is glutinous substance which mainly consists of polysaccharides, proteins and uranides. Dried up mucilage or concentrated mucilage is called as gum3. Gums and mucilages are insoluble in alcohol but liquefy or swell in water. They are translucent, amorphous substances that are frequently produced in higher plants as a protective after injury4. The main difference between them is mucilage do not dissolve in water where as gum dissolve in water. They are widely used in pharmaceutical industries as thickeners, water retention agents, suspending agents, disintegrant and gelling agent3.

 

 

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