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THE PHARMA REVIEW (NOVEMBER DECEMBER 2012)

Simultaneous Estimation of Amoxicillin Trihydrate and Dicloxacillin in Bulk and Capsule Dosage Form By UV-Spectrophotometry

S Srinivas, S. B. Puranik, KA Sridhar, Venkateswari P, & A Ramprasad Reddy

Introduction:
 
The present study describes simple, accurate, precise and cost effective UV Spectrophotometric method for the simultaneous estimation of Amoxicillin trihydrate (AMX) and Dicloxacillin (DCLX) in bulk and capsule dosage form. The solvent used was 0.1N NaOH and the absorption maxima for amoxicillin trihydrate and Dicloxacillin were found to be 246nm and 274nm respectively. A linear response was observed in the range of 10-70g/mL with a correlation coefficient of 0.999 for AMX and DCLX respectively. The method was then validated for different parameters like accuracy, precision, sensitivity and linearity as per ICH Q2 (International Conference on Harmonization) guidelines. This method can be used for the simultaneous estimation of AMX and DCLX in quality control of formulation without interference of excepients.

 

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