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THE PHARMA REVIEW (NOVEMBER - DECEMBER 2016)

Biofilm Remediation in a Pharmaceutical Purified Water System A Case Study

Sunil S Chiplunkar Shrikar Pande, Sumalatha, S. & Krishna Chaitanya, K.S.

Introduction: This article provides a case study for the use of the combination of Hydrogen peroxide and Peroxyacid to decontaminate a Purified Water production and delivery system in a Pharmaceutical establishment. While there are number of potential sources of contamination in storage and delivery systems for purified and sterile water, one of the most common problems facing the purified water production and delivery is the prevention and removal of biofilms. Once established, biofilm-producing microbes cannot be effectively removed using conventional antimicrobial reagents (Alison, 2003; Tachikawa et al., 2009). The removal of biofilms from the wetted surfaces of the Purified Water systems is thus a pre-requisite for the maintenance of high-purity water quality compedial water systems in Pharma. Elimination of this source of microbial contamination is critical, but can be exceedingly difficult (Hanley-Onken & Cohen, 2013). 

 

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