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THE PHARMA REVIEW (NOVEMBER - DECEMBER 2016)

Fast Dissolving Buccal Films

T.Balakrishna*, S.Vidyadhara, T.E.G.K.Murthy, R.L.C.Sasidhar & J.Lahari *

Introduction: Now a days, there has been increased interest for fast-dissolving drug delivery systems that are gaining a lot of importance and acceptance as novel drug delivery systems, to improve the safety, efficacy and patient compliance, thereby increasing the product shelf life. These are solid dosage forms which are thin polymeric strips incorporating and delivering pharmaceutical active ingredients & when placed in the mouth dissolves rapidly in a short period of time without drinking water or chewing. It was first developed in 1970ís alternative to tablet and capsule. These are also called as Oral thin films, buccal films/strips, and Oral strips. These buccal films have a capacity to deliver the drug systemically through intra-gastric, sublingual or buccal route of administration and also have been used for local action. The buccal film is a more elegant dosage form which can improve bioavailability, when compared to other dosage forms as it bypasses the hepatic first pass metabolism. It is most valuable and palatable dosage form due to its small size, small dose and thickness of the film. Moreover, it does not require swallowing of the drug, which is most suitable for pediatric as well as geriatric patients. These are used in many allergic conditions like cold and cough, sore throat, nausea, pain, mouth ulcers, CNS disorders and CVS disorders. It includes various ingredients for its formulation which includes polymers, active pharmaceutical ingredient, film stabilizing agents, plasticizers, sweeteners, flavors, colors, saliva stimulating agents, surfactants etc. 

 

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