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THE PHARMA REVIEW (NOVEMBER - DECEMBER 2017)

Personalized Nanomedicine in Treatment of Alzheimer’s Disease

Rashmin B Patel1*, Mrunali R Patel1 & Shivam D. Thakore2

Introduction: Alzheimer’s disease (AD) is debilitating progressive disorder of central nervous system (CNS) characterized by loss in cognitive function due to loss in cholinergic activity, abnormal protein deposits in brain and neuroinflammation. The treatment for AD is hampered due to inability of AD agents to cross Blood Brain Barrier (BBB) and limited benefits of conventional methods (For example tablets or solution through oral routes etc.) in treatment of neurological disorders. Nanomedicine (NM) is most developing area in healthcare sector as a part of nanotechnology. Scientists worldwide are finding the alternatives to use the currently available techniques in nano-scale. Drug delivery is highly versatile area of healthcare sector which have broad scope of using nanotechnology for improving the drug delivery which is major concern in the treatment of neurological disorders due to entry restrictions led by BBB. NM has come into picture, which has more benefits than any associated risks. This article will brief out readers about NM and its applications in AD. Further, it explains how applications of therapeutic agents can be improved with personalized choice of treatment in AD using intranasal route and NM concept. This fact is also later explained by current research publications which signifies the personalized drug delivery in AD through intranasal route and NM can bring the revolutionary change in treatment of AD. 

 

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