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Abstract: The goal of any drug delivery system is
to provide on the therapeutic amount of drug to the
proper site in the body and also to achieve and maintain
drug concentration .The site specific or targeted
delivery combined with delivery at on optimal rate would
not only improve the efficacy of a drug but would also
reduce the possibility of unwanted toxic side effects,
thus improving the therapeutic index .Microspheres
possess several advantages over other targeted drug
delivery systems like larger drug loading capacity ,
greater, stability and cotrolled over extended period of
time.
HPMC Microspheres were prepared by heat stabilization
method in the presence of span 80 . Metformin was used
as the model drug. Drug to polymer ratio is
1:0.5,1;1,1:2 shows maximum yield and highest entrapment
and maximum encapsulation was found to be 94% w/w. The
microspheres prepared in the ratio of 1:0.5 release
96.13% and 1:2 ratios releases 92.72% at8 hours
respectively. The invitro release profiles of
microspheres confirmed that the pure drug and marketed
releases faster than the microsphere formulations. So
this HPMC Microspheres are suitable for oral sustained
release of Metformin HCL.
Introduction
An ideal drug delivery system, in addition being
therapeutically effective and nontoxic, should achieve
and maintain effective therapeutic plasma concentration
for extended period of time.Metformin HCL is a oral
hypoglycemic drugs and used as a management of
hyperglycemia in noninsulin dependentdiabetes
mellitus.It is a Biguanides, Microspheres can be defined
as solid, approximately spherical particals ranging from
1 to 1000. They are made up of poilymeric, waxy or other
protective materials, which are biodegradable synthetic
polymers and modified natural products such as starches,
gums, proteins, fats and waxes. The natural polymers
include polylactic acid and polyglycolic acid.
Microsphere drug administration offers a number of
advantages in therapeutics, where the controlled release
s of dr4ug delivery as well as the precdictable and
reproducible drug release kinetics are important
features of them. The aim of this work is to investigate
the possibility of obtaining is prolonged relatively
constant effective level of Metformin from the HPMC
microsphere formulation using HPMC and albumin as
carriers.
Materials and Methods
Metformin HCL is supplied by Karnataka antibiotics,
Bangalore, HPMC are supplied by (L.R, Loba chemie pvt.
Ltd. Mumbai), Acetone is supplied Ranbaxy fine chemicals
ltd, delhi, Diethyle ether(, Merck limited,mumbai,)
Tween-80, Span-80 (,Nice chemicals, cochin,) Petrolium
ether, Alloxan (Sigma chemicals, Bangalore).
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