Comparative Study on Oral and Transdermal Administration of Diltiazem Hydrochloride in Rabbits

Abstract: Transdermal patches of diltiazem hydrochloride were formulated employing ethyl cellulose (2%) as film formers and its pharmacokinetic parameters were compared with that of oral administration in male New Zealand albino rabbits. The estimation of diltiazem in serum was carried out by RP HPLC method. The parameters such as maximum serum concentration (Cmax), time for peak serum concentration (tmax), mean residence time (MRT) and area under curve (AUC0 - ¥) were significantly (p< 0.001) differed following transdermal administration compared to oral administration. The metabolite was found at the chromatogram of oral administration at 1 hr; where as transdermal route showed negligible amount of metabolite even at 4 hrs. It was concluded that the relative rate of extensive first pass metabolism was significantly reduced in transdermal administration, resulted in increased relative bioavailability and reduced frequency of administration.

The above content is an abstract only. For the full Article please contact:
KONGPOSH Publications Pvt. Ltd.
ICS House, C-19, Commercial Complex, SDA, Opp. IIT Gate, New Delhi, India -110016
Tel.: 26855839, 20057149, Fax: 91-11-26855876
Email: info@kppub.com / fpc@vsnl.com, Website: http://www.kppub.com