Enhancement of Solubility of Valdecoxib by Solid Dispersion Technique

Abstract : Although there was a great interest in solid dispersion systems during the past four decades to increase dissolution rate and bioavailability of poorly water-soluble drugs, their commercial use has been very limited, primarily because of manufacturing difficulties and stability problems. Solid dispersions of drugs were generally produced by melt or solvent evaporation methods. The materials, which were usually semisolid and waxy in nature, were hardened by cooling to very low temperatures. They were then pulverized, sieved, mixed with relatively large amounts of excipients. Here we tried the improving the solubility of valdecoxib by using different carriers and solid dispersion techniques. Solid dispersions demonstrated a higher dissolution rate than pure drug. The valdecoxib: PEG 6000 shows highest dissolution rate than the other formulations. Hence, the solid dispersion technique with PEG 6000 provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.

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