Estimation of Fenoverine Hydrochloride in Pharmaceutical Dosage Forms by RP HPLC

Abstract: A simple, precise and reproducible method has been developed and validated for the estimation of Fenoverine Hydrochloride in pharmaceutical dosage forms by RP HPLC. Literature survey revealed that no method has been reported for the estimation of Fenoverine Hydrochloride except its determination in human plasma. The separation was achieved using C-18 ODS/RP column (5 micron/25 cm x4.6 mm) in isocratic mode with mobile phase ammonium acetate and acetonitrile (50:50 v/v) at a flow rate of 1.5 ml/min, detection was carried out at 254 nm using a UV detector. The retention time was 5.5 min. Dilution of standard and sample were made in mobile phase. Recovery study was carried out by adding known quantity of standard drug in the preanalysed test solution and % recovery is calculated in each case. The percentage recovery study of Fenoverine Hydrochloride was found to be 98.5 to 100.1% w/w respectively. The proposed method was found to be accurate, precise, simple and rapid which could be easily used for routine analysis.

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