Abstract: In the present investigation an attempt has been made to increase therapeutic efficacy, reduced frequency of administration and improved patient compliance by developing controlled release matrix tablets of Diltiazem hydrochloride. Diltiazem hydrochloride was formulated as oral controlled release matrix tablets by using poly(ethylene oxides).
{Polyox WSR 303 & Polyox WSR 301}. In this study the matrix tablets were prepared by direct compression method. The drug release from the formulations followed first order kinetics and were linear with Higuchi plots. The Invitro drug release studies for different formulations were also compared with drug release studies of commercially available products. The results indicated that the formulations containing drug and polymer ratio 1:1 and 1:1.5 for Polyox WSR 303 and Polyox WSR 301 for Diltiazem Hydrochloride are linear with drug release rates of marketed product. |
The above content is an abstract only. For the full Article please contact:
KONGPOSH Publications Pvt. Ltd.
ICS House, C-19, Commercial Complex, SDA, Opp. IIT Gate, New Delhi, India -110016
Tel.: 26855839, 20057149, Fax: 91-11-26855876
Email:
info@kppub.com /
fpc@vsnl.com, Website:
http://www.kppub.com |
