Abstract: A simple, rapid and economical method for simultaneous estimation of aceclofenac and paracetamol in tablet formulation has been developed. Paracetamol is quantized using two wavelengths, 230 nm and 275 nm where as aceclofenac is quantized using two wavelengths, 224 nm and 269 nm in methanol. The Beer's law is obeyed by paracetamol and aceclofenac in concentration range of 0-30 µg/ml and 0-50µg/ml for aceclofenac and paracetamol respectively.
Introduction
Aceclofenac (ACF), {[2-(2`, 6`-dichlorophenyl) amino] phenyl acetoxyacetic acid} is a new phenyl acetic acid derivative with potent analgesic and anti-inflammatory properties with improved gastric tolerance. Paracetamol (PCM), chemically 4-hydroxy acetanilide, is a centrally and peripherally acting analgesic, antipyretic agent. A combination of these two drugs containing aceclofenac (100 mg) and paracetamol (500 mg) is available commercially by different manufacturers. This combination is use for pain and management of rheumatic disorders. B.P.1 describes titrimetric method for estimation of aceclofenac. Paracetamol is official in I.P.2, B.P.1 and U.S.P.3 which describes titrimetric and spectrophotometric methods for its estimation. Only few methods4-9 have been reported for determination of aceclofenac individually, whereas many methods9-13 have been described in literature for determination of paracetamol alone or in combination with other drugs. The review of the literature revealed that no method is as yet reported for the simultaneous estimation of both the drugs in combined dosage form. Present paper described simple, accurate and reproducible two wavelength spectrophotometric method for simultaneous estimation of two drugs in tablet formulation. |
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