A simple, rapid and accurate spectrophotometric method
has been developed for quantitative estimation of
Efavirenz in bulk and tablets. In methanol: water
(80:20), Efavirenz exhibits absorption at 245.0 nm and
method obeys Beer’s law at the concentration range of
5-50µg/mL. The percentage label claim was found in the
range of 98-102%. The proposed method was validated
statistically and recovery studies.
and non-nucleoside HIV-I reverse transcriptase inhibitor
used combination therapy for a treatment of HIV-1
infection.2 Literature survey revealed that Rapid method
for the quantitative determination of efavirenz in human
plasma3, HPTLC4 and HPLC5 Method are available for
estimation of Efavirenz alone and in Combinations with
other drugs6. Therefore, it was thought worthwhile to
develop simple accurate and reliable spectrophotometric
method for estimation of Efavirenz in bulk and in tablet
dosage form using methanol: water (80:20) as a solvent.
All the chemicals used were of analytical grade.
Spectral and absorbance measurement were made on
Systronics Double beam UV-Visible spectrophotometer 2203
with 10 mm matched quartz cells.
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