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THE PHARMA REVIEW (SEPTEMBER - OCTOBER 2010)

A Validated RP-HPLC Method for Simultaneous Determination of 
Losartan and Perindopril in Solid Dosage Form

Hemlata M. Nimje, R. J. Oswal, S. M. Kashid, Nilima Nimje

Abstract
A simple, rapid and accurate spectrophotometric method has been developed for quantitative estimation of Efavirenz in bulk and tablets. In methanol: water (80:20), Efavirenz exhibits absorption at 245.0 nm and method obeys Beer’s law at the concentration range of 5-50g/mL. The percentage label claim was found in the range of 98-102%. The proposed method was validated statistically and recovery studies. 

 

Introduction
Efavirenz, 4(S)-6-chloro-4(cyclo-propylethynyl)-1,4-dihydro-4-(trifluromethyl)-2H-3,1-benzoxazin-2-one1 and non-nucleoside HIV-I reverse transcriptase inhibitor used combination therapy for a treatment of HIV-1 infection.2 Literature survey revealed that Rapid method for the quantitative determination of efavirenz in human plasma3, HPTLC4 and HPLC5 Method are available for estimation of Efavirenz alone and in Combinations with other drugs6. Therefore, it was thought worthwhile to develop simple accurate and reliable spectrophotometric method for estimation of Efavirenz in bulk and in tablet dosage form using methanol: water (80:20) as a solvent.
All the chemicals used were of analytical grade. Spectral and absorbance measurement were made on Systronics Double beam UV-Visible spectrophotometer 2203 with 10 mm matched quartz cells.

 

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