Formulation and Evaluation of Mouth Dissolving Tablets of Carbamazepine

Margret Chandira, Debjit Bhowmik, B. Jayakar, Abhijita, K. P. Sampath Kumar

The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients who have swallowing difficulties. Carbamazepine is an anticonvulsant drug used primarily in the treatment of epilepsy. Mouth dissolving tablets of carbamazepine were formulated by superdisintegrant addition method by direct compression technique by superdisintegrants such as crospovidone, kyron T-314 and L-HPC in different concentration like 5%, 7.5% and 10%. All the formulations were evaluated for weight variation, hardness, friability, drug content, in-vitro disintegration time, wetting time, in-vitro dissolution study. Formulation F9 shows the lowest disintegration time (25 seconds) and wetting time (32seconds). In-vitro dissolution studies revealed that formulation F9 showed 100% drug release at the end of 6 minutes.
An ideal dosage regimen in the drug therapy of any disease is the one, which immediately attains the desire therapeutics concentration of drug in plasma (or at the site of action) and maintains it constant for the entire duration of treatment. This is possible through administration of conventional dosage form in a particular dose and at a particular frequency Thus drug may be administered by variety of routes in a variety of dosage forms. Discussion of the characterization of the mouth dissolving tablets of carbamazepine with various super disintegrants Crospovidone, KyronT-314 and L-HPC were tried for formulation of mouth dissolve tablets. The concentration of superdisintegrant was taken 5, 7.5 and 10 %. The powder blend was evaluated for angle of repose, hausner ratio and % compressibility. The prepared tablet was evaluated for physical parameter, Wetting time, In vitro disintegration time, Assay and In vitro drug release.


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