The demand for mouth dissolving tablets has been
growing, during the last decade especially for geriatric
and pediatric patients who have swallowing difficulties.
Carbamazepine is an anticonvulsant drug used primarily
in the treatment of epilepsy. Mouth dissolving tablets
of carbamazepine were formulated by superdisintegrant
addition method by direct compression technique by
superdisintegrants such as crospovidone, kyron T-314 and
L-HPC in different concentration like 5%, 7.5% and 10%.
All the formulations were evaluated for weight
variation, hardness, friability, drug content, in-vitro
disintegration time, wetting time, in-vitro dissolution
study. Formulation F9 shows the lowest disintegration
time (25 seconds) and wetting time (32seconds). In-vitro
dissolution studies revealed that formulation F9 showed
100% drug release at the end of 6 minutes.
An ideal dosage regimen in the drug therapy of any
disease is the one, which immediately attains the desire
therapeutics concentration of drug in plasma (or at the
site of action) and maintains it constant for the entire
duration of treatment. This is possible through
administration of conventional dosage form in a
particular dose and at a particular frequency Thus drug
may be administered by variety of routes in a variety of
dosage forms. Discussion of the characterization of the
mouth dissolving tablets of carbamazepine with various
super disintegrants Crospovidone, KyronT-314 and L-HPC
were tried for formulation of mouth dissolve tablets.
The concentration of superdisintegrant was taken 5, 7.5
and 10 %. The powder blend was evaluated for angle of
repose, hausner ratio and % compressibility. The
prepared tablet was evaluated for physical parameter,
Wetting time, In vitro disintegration time, Assay and In
vitro drug release.
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