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THE PHARMA REVIEW (SEPTEMBER - OCTOBER 2010)

Formulation, Optimization and Evaluation of Metformin Microspheres Prepared By W/O/O Double Emulsion Solvent Diffusion Technique

Jovita Kanoujia, Kanchan Sonker, Koshy Mamman Kymonil, Manisha Pandey, Shubhini A.Saraf

Abstract
The present investigation deals with the formulation and evaluation of metformin loaded ethylcellulose microspheres by w/o/o double emulsion solvent diffusion method with high entrapment capacity and sustained release action. Various batches were prepared in which mixed solvent system consisting of acetonitrile and dichloromethane in a 1:1 ratio and light liquid paraffin was selected as primary and secondary oil phases, respectively span 80 was used as the secondary surfactant for stabilizing the external oil phase. The influence of processing and formulation parameters i.e., drug: polymer ratio, concentration of surfactant and volume of processing medium on particle size, drug loading, entrapment efficiency and in-vitro release were investigated. The drug-loaded microspheres showed 45-81% entrapment capacity. The in-vitro release followed Higuchi Kinetics (R2=0.918) and was diffusion controlled. The in-vitro release profile could be altered significantly by changing various processing and formulation parameters to give sustained release of drug from the microspheres.

 

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