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THE PHARMA REVIEW (SEPTEMBER - OCTOBER 2010)

Newer Anticonvulsants: An Insight into The Adverse Effects

Seema Jain, Nidhi Bharal Agarwal

Abstract
Epilepsy is a devastating neurological disorder affecting 1 % population worldwide. Recently, newer anticonvulsants have emerged as a ray of hope for the patients suffering from refractory epilepsy. Although several reports claimed at their safer use in patients yet these have been found associated with several adverse events. The present review concentrates on these serious adverse effects associated with newer anticonvulsants.
 
Lamotrigine
Lamotrigine is used as adjunctive therapy in adults with partial seizures. It also has therapeutic application in generalised seizures of Lennox-Gastaut syndrome and generalised epilepsies including idiopathic generalised epilepsies. The anticonvulsant effects of lamotrigine could be due to the inhibition of sodium currents by interacting with the inactivated channel and inhibitory effects on the release of glutamate.

 

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