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THE PHARMA REVIEW (SEPTEMBER - OCTOBER 2011)

Development of Fast Disintegrating Tablets of Taste Masked Metaclopramide Hydrodhloride

Shailesh Sharma, Ghanshyam Das Gupta, Govardhan Sharma

Abstract
The aim of the present investigation is to formulate and evaluate fast disintegrating tablets of taste masked metaclopramide hydrochloride tablet. In the primary stage, the bitter taste of metaclopramide hydrochloride was masked by the batch process using ion exchange resins. The masked drug-resin complex was evaluated for taste and for chemical changes by the infrared spectroscopy studies. At the ratio of 1:5 maximum drug was complexed with resin at one hour swelling, two hour drug loading at pH 6.8. The prepared drug resin complex was incorporated in fast disintegrating tablets. The three superdisintegratns were added in these tablets at 3-4% (w/w) of the tablets. Due to the addition of superdisintegrants tablets may disintegrants with in a minute. The fast disintegration results in fast dissolution of the metaclopramide. These tablets were very helpful in the cases nausea and vomiting in children and pregnant women.
 
Introduction
In accordance with the transition to an aging society and changes in the living environment, a demand has arisen for the development of drug dosage forms that can be readily handled and taken by elderly, children or patients whose intake of water is restricted. For example, a dosage form which can be taken without water is useful in the case of the acute onset of a symptom. Thus attempts have been made to develop an orally disintegrating dosage form which, when taken in the oral cavity, rapidly disintegrates or dissolves merely in the saliva or a small amount of water.1 Metoclopramide Hydrochloride (MTH), 4-amino-5-chloro-N-[2-(diethylamino) ethyl]-2 methoxybenzamidemonohydrochloride monohydrate, is one of the potent antiemetic drug. MTH apparently antagonizes dopamine at the receptor sites. This action can explain its sedative, central antiemetic (blocks dopamine in the chemo-receptor trigger zone), extrapyrimidal, and prolactin secretion stimulation effects.2 In general emesis is preceded with nausea and in such case it is difficult to administer drug with a glass of water, hence it is beneficial to administer such drugs as FDTs. Metoclopramide Hydrochloride (MTH) is an intensely bitter drug, hence it is to be taste masked first.
Palatable formulation development is one of the most difficult tasks, although various taste masking techniques such as the addition of sweeteners and flavors, coating with polymers, adsorption to ion-exchange resin, and chemical modifications such as the use of insoluble prodrugs have been reported.3
Ion Exchange (IE) Resins for taste masking involves the reversible interchange of ions (of like charge) between a liquid and a solid phase, with no radical change in the structure and properties of the solid.

 

 

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