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THE PHARMA REVIEW (SEPTEMBER - OCTOBER 2016)

In Vitro Study of Chitosan Anionic Polymer Based Tablets for Extended Release of Niacin

Asha Thomas*, Snehalata Kute, Amrut Kadam, Rabindra Nanda, Lata Kothapalli & Snehal Karanjkhele

Introduction: Niacin (pKa: 2.17) is a lipid-altering agent of BCS class 1 drug with plasma half-life of 20-48 min. To extend the release of niacin in biological fluids, attempts were made to formulate niacin tablets using different proportions of chitosan-xanthan gum polymer matrix. The tablet formulations (F1 to F7) were prepared by wet granulation method, characterized by suitable physicochemical parameters. For the assay and quantitative determination of niacinand in vitro dissolution study carried out under simulated gastrointestinal conditions, a simple, precise and reproducible isocratic RP-HPLC method was developed using C-18 as stationary phase; ammonium acetate buffer: acetonitrile (45:55) as mobile phase at a flow rate of 1ml/min with UV detection at 261nm. Atorvastatin was employed as an internal standard. Retention time for niacin and atorvastatin was found to be 2.29 and 6.93 min respectively. The calibration curves were linear in the range of 5-150 μg/ml (r2 = 0.995) for niacin. Chitosan-xanthan gum matrix system in a ratio of 1:1 exhibited the best extended-release behavior and could prolong drug release up to 24 h. Fourier transform infrared spectroscopy (FTIR) study demonstrated that polyelectrolyte complexes (PECs) were formed on the tablet surface, which plays an important role in retarding erosion and swelling of the matrix in the later stage, thereby extending the release of niacin. 

 

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