Abstract: Three simple and sensitive visible spectrophotometric methods have been developed for the determination of Alfuzosin hydrochloride (AFZ) in pharmaceutical formulations. Method A is based on the oxidative coupling reaction of AFZ with thymol under alkaline conditions in presence of sodium hypochlorite and the colored product formed was measured at 510 nm. Method B is based on the reaction of AFZ with cobalt thocyanate and the colored complex was measured at 630 nm. Method C is based on the formation of a colored internal salt between AFZ and citric acid in presence of acetic anhydride, which absorbs maximally at 580 nm. Beer's law is obeyed in the concentration ranges 8-40, 20-100 and 5-25 ìg/ml for method A, B and C respectively. The methods have been applied to the determination of AFZ in commercial tablets. Results of analysis were validated statistically and are found to accurate and precise.
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