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Title |
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Sethi’s HPTLC Content Uniformity of
Pharmaceutical Formulations
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Author |
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Dr. P.D.Sethi
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Price |
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Rs. 2450/- |
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Pages |
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121 |
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Publishers |
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The book
entitled “Sethi’s HPTLC content uniformity of
pharmaceutical Formulations” is an author’s
successful attempt to use HPTLC technique for
content uniformity test as an alternate method over
HPLC, being the method of choice in all leading
pharmacopoeias i.e. IP, BP, USP, EP etc.
In this book Author has given detailed method of
analysis for content uniformity test by HPTLC. There
are 45 Protocol for different 45 pharmaceutical
formulations. The book consists mainly two parts.
Part-A from page number 1-60 , having 30
formulations containing one active substance and
Part-B from page number 62-121, having 15
formulations containing two active substances. Each
protocol has been described with Formulation, Drug
classification, Dosage form, sample/standard
preparation, chromatographic equipments, sample
application scheme, chromatographic condition,
densitometric evaluation and densitogram. RSD for
both standard and sample has been calculated. At the
end of the book a comparative Analytical data for
content uniformity Test by HPTLC and HPLC has been
given for (i) Mean assay (%) values of 10 individual
dosage (ii) Assay range (iii) RSD (%). Quite
comparable results support the Author’s claim for
use of HPTLC for content uniformity test as an
alternate technique.
As we know, in the content uniformity test by HPTLC
all the ten dosage forms of a sample and five
replicates of standards can be analyzed
simultaneously while in HPLC, we have to run one by
one. In this way both time and money could be saved.
In my personal opinion HPTLC is a versatile, simple,
fast and cost effective technique.
Dr. P.D. Sethi is well known Authority in the field
of pharmaceutical analysis. He is PhD from Madras
University in pharmacognosy and Former Director of
Central Drug testing laboratory Mumbai. He has
written a number of books in pharmaceutical Analysis
using different analytical techniques like UV-vis
spectrophotometry, TLC, HPTLC and HPLC.
I would like to congratulate, Dr. P.D. Sethi for
such an excellent attempt to compile this unique
book. The book would be helpful for Analyst working
in quality control of a Pharmaceutical Industry,
Drug testing Laboratory and R&D centers.
Book
Reviewed By: Dr. R.A. Singh, Director, Regional
Drugs Testing Laboratory, Chandigarh.
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Title |
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Polyvinylpyrrolidone Excipient For
Pharmaceuticals
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Author |
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Volker BÜhler
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Springer (India) Private Limited |
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This book
is a comprehensive coverage on polyvinylpyrrolidone
(Povidone) as a pharmaceutical excipients.
Pharmaceutical excipients is an important component
of pharmaceutical preparations, its role is to
ensure that drugs must selectively transported to
the target position the body with certain speed and
time of release. Therefore, for better efficacy of
the medicines, the selection of appropriate
excipients is very important during manufacturing of
the medicines.
For this purpose overall knowledge regarding physico-chemical
properties, pharmaceutical application and
toxicological information of different kinds of
excipients is very essential. As this book is a
outcome of exclusive informative collection about
the physico-chemical properties, qualitative and
quantitative analytical methods, pharmaceutical
applications and toxicological information of
soluble polyvinyl pyrrolidone (povidone), insoluble
polyvinyl pyrrolidone crospovidone) and
vinylpyrrolidone-vinylacetate copolymer copovidone),
it is very useful to those who are looking for the
book deals with the most valuable pharmaceutical
excipients like povidone.
The whole book is divided into six well chapters and
the author has very meticulously shared his
knowledge, experience and expertise in these
chapters. In this well written book the author has
documented all important information like general
synthesis, molecular structure, synonyms, product
properties, analytical methods, pharmaceutical
applications, and toxicological data of
polyvinylpyrrolidone and its copolymer.
Finally, this book which is a collection of very
useful information and outcome of enriched knowledge
and vast experience of the author is not only
beneficial to all the persons involved in the field
of pharmacy and health science for their academic
and research purposes but also equally important to
the other scientific persons interested in the
pharmacy.
It is believed that because of the enriched text and
good systematic presentation with impressive
language, this book will definitely finds its place
among all the book lovers and researchers who are
looking for a quality book dealing with the
excipients.
Book
Reviewed By: Dr. Dilip Kumar Panda, Central
Drugs Laboratory, Kolkata
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Title |
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St. John's Wort or Hypericum
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Author |
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Dr. Ravindernath Kaul, Germany
durgaravi.kaul@gmail.com
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St. John's Wort or Hypericum
St. John's
Wort or Hypericum has become an important source for
phytotherapeutic preparation especially in North
America and Europe. It is particularly well known
for its uses in the treatment of mild forms of
depression and is a classic example of an indigenous
European medicinal plant transformed into a 'modern'
herbal remedy. Sales of preparations containing St.
John's Wort have soared in recent years. The book
covers all relevant aspects of this drug. Detailed
discussions on the plant's botanical and
pharmacognostical characteristics, the natural
product know from the species, quality control
aspects (including the standardisation of extracts),
pharmacological (pharmacodynamic and some
pharmacokinetic) studies in animals and humans and
clinical studies included is impressive. Some of
these use a very rigorous methodology, thus giving
good evidence for the species' clinical efficacy.
The continuing debate whether hypericin (a
naphtodinathrone) or hyoperforin (a complex
terpenoid) is more relevant for the clinically
observed effects is not discussed specifically, but
since the author provides numerous pharmacological
data on the various types of extracts and on the
pure compounds, the reader may well draw his/her own
conclusions.
The book provides a very good overview on all
pharmaceutical aspects of this important medicinal
plant. Obviously in a rapidly developing field new
important data come in constantly. The recent
finding of the risk of interactions between
hypericum extracts, and, for example,
anti-coagulants has not yet been included.
It is therefore to be hoped that the book will be
updated regularly. Because of the strong interest in
this 'herbal product' in English-speaking countries,
an edition in English would be very useful.
This book is part of a series on medicinal plants,
which have yielded important phytotherapeutic
preparations (e.g. Crataegus spp., Ginkgo biloba).
Hopefully this series will be expanded in order to
summarize basic scientific information about widely
used medicinal plants. From an ethnopharmacological
perspective, the book is of particular interest
since it shows the multitude of studies required to
transform a 'traditional' medicine into clinically
used phytotherapeutic preparations. But it also
clearly demonstrates that it is worth the effort.
This very good book is of relevance to anyone
interested in European phytotherapy, or in medicinal
plant research in general and, of course, it is a
'must' for all working on St. John's Wort.
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Title |
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Reflections, on life changes
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Author |
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VASUNDHARA RAMANUJAN, MOHAMMAD AKMAL, MD
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Time had
stood still. Stunned into a silence, we felt our
lives suspended by a thin, fragile rope with
uncertainty looming large. Our fifteen and a half
year old son’s kidneys were nearly shut down.
“Chronic kidney failure,” was the words used by the
specialist. The suddenness had made us apprehensive
and we smelt danger, discomforted by the newness of
this disease that was supposedly associated with
adults. To regain our lost composure we needed to
find some good solutions.
Using analytical skills, armed with some courage and
understanding, we took baby steps in gaining
knowledge. It meant closely studying every aspect of
the disease. As we unraveled the mystery of kidney
failure, we learnt the gravity of the disease which
kept the patient involved with diet, medication,
blood pressure monitoring, and periodic check- ups.
Each of these was directly related to food and fluid
intake as a measure against urine outputs.
The family worked together, on a set goal of a
transplant option as soon as my son began dialysis.
I offered my kidney. It was a practical decision. My
husband was a diabetic and my elder son just
seventeen years. A few years later, after I finally
managed to donate my kidney against all odds of
fighting a breast cancer, the horrific chemotherapy
and radiation, I experienced many other feelings. It
was not joy, nor was it pride, but a completely new
sense of being me, myself.
Life had changed dramatically but I drew comfort of
having reached the safe zone.
I saw the whole world on the other side. They did
not see, know, or understand how and why our lives
had changed. I made it my responsibility of telling
how a young man faced the life threatening disease,
sought treatments and finally found joy in his life.
Importantly tell people why they should protect
themselves against a kidney failure by taking
preventive steps in certain health conditions.
I realized that managing life with the disease was
difficult, sometimes the huge treatment cost made it
unaffordable for some patients. Finding a willing
donor was a huge task, and many were unsuccessful in
even arranging a transplant. Above all a cancer
survivor qualifying for a kidney donation was
uncommon.
“Shades of Life” is an inspiring book that could
touch people in every walk of life. The protagonist
made it his mission to find joy and lead a
wonderful, near normal life. He lost his kidney
again in 2006. After many earth-shattering
experiences, his elder brother donated a kidney in
2009. In these 15 years, my son had graduated from
Mumbai’s Xavier’s College, did Masters in IIT, Powai,
graduated as a Doctorate in Physics from University
of Southern California and is now on a post
doctorate at University of Alberta, Canada.
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Title |
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PHARMACOKINETICS AND THERAPEUTIC DRUG
MONITORING
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Author |
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Dr. Nitin Mahurkar and O.S. Kamalapurkar
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Price |
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Rs. 265, Overseas – Rs. 350
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Pages |
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280 |
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Publishers |
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Vallabh Prakashan, New Delhi |
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Drug
research encompasses several diverse disciplines
united by a common goal, namely the development of
novel therapeutic agents. Pharmacokinetics and
Therapeutic Drug Monitoring has assumed a great
value in drug discovery. Many new combinations of
drugs are being invented and made available
frequently. The knowledge of pharmacokinetics is a
thrust area for optimizing safe and efficacious drug
therapy. Also, pharmacokinetics has now become a
formal course of study especially with introduction
of Pharm. D course by the Pharmacy Council of India.
In the initial few chapters of the book, the
fundamentals of rate kinetics, factors defining the
Absorption, Distribution, Metabolism and Excretion
of a drug are discussed with suitable examples. The
chapters on compartment models of `Pharmacokinetics’
are discussed as one, two and three compartment
models based on route of administration of the
drugs. The model independent kinetics has also been
explained in detail. The chapter on dosage regimen
discusses the concept of various parameters that are
important in determining the quantum of dose and its
use. The concept of `Therapeutic Drug Monitoring’ (TDM)
of some selected drugs is also discussed.
To keep pace with the advances, the authors have
made a sincere effort towards elaborating the
comprehensive fundamental principles of
`Pharmacokinetics’ in a simple and easily
understandable approach. Overall the book presents
the subject in a simple and lucid manner and would
be a good reference resource for all pharmacy
students.
Book Reviewed by Mr. Raman Sehgal
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Title |
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Pharmaceutical History of India
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Author |
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Professor Harkishan Singh
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Pages |
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322 |
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Publishers |
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Vallabh Prakashan, Delhi - 110 033 |
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India
would have lost the history of pharmaceutical
developments, thanks to the painstaking efforts of
Professor Harkishan Singh that has given us a wealth
of literature on this subject. Since last 20 years,
he has been working to explore the history of modern
pharmacy in India covering the span of last few
centuries including the pharmaceutical progress in
independent India. He has collected a great deal of
historical material through his travels to different
libraries in India and abroad and by large and
scholarly correspondence. He has compiled his
research work in 22 chapters in his latest book
“Pharmaceutical History of India”.
Chapter 1 begins with the Introduction of the
arrival of European powers on the Indian
subcontinent with the coming of Portuguese Vasco da
Gama in 1498. Subsequently Dutch and French came
followed by British, who took control of the vast
land and East India Company was established.
Portuguese teacher and physician Garcia da Orta who
stayed in Goa for three decades (1534-1564) studied
Indian material medica and wrote extensively on this
subject.
Chapter 2 deals with Colonial Professions of
Medicine and Pharmacy. The Indian Medical Service (I.M.S.)
was founded in British India which led to the
establishment of medical education first in Calcutta
and then in Madras. Apothecaries and hospitals
assistants classes were also started. Pharmacy
profession stood neglected during the British rule
and overall situation with regard to drugs and
practice of pharmacy remained a grave concern.
Chapter 3 provides historical aspects of British
Period Pharmacies. One can know about M/s K.R.
Chandran, S.F. Ranji, B.K. Paul, I.G. Gajjar,
Jalbhai Billimoria, Lalchand Dodha, K. Venkatapathi
Naidu, R.B. Sen, Ratan Lal Gupta and Dr Shaib Singh
on one side and great pharmacies of yesteryears like
Smith, Stanistreet & Co (Calcutta), S.Brothers
(Bombay), Bill & Co (Bombay), Appah & Co (Madras),
Imperial Medical Hall / H.C. Sen & Co (Delhi) and
Beli Ram & Brothers (Bombay), to mention a few of
them.
Chapter 4 deals with Colonial Overseas Drug Trade
with special reference to foreign trade in general,
export of raw drugs and import of drugs and
medicines.
Chapter 5 describes Qualified Indian Chemists and
Druggists, which laid the process for the profession
of pharmacy. The chemists and druggists’ class
started in Madras in 1860. The contributions of
S.Rajagopal Naidu are recorded. For the uniform
system of education for qualification as
pharmacists, Pharmaceutical Society of India, the
oldest organisation of its type was founded in 1925
with such prominent architects and builders like
Wilfred Pereira and A.N. Lazarus.
Chapter 6 Compounders’ Community illustrates greatly
and traces the history in Bengal, Madras, Bombay and
other provinces in times as early as 1881. All India
Compounders’ and Dispensers’ Association was founded
in 1923 and All Bengal Compounders’ Association in
1929. The contributions of Raj Bahadur and K.K.
Acharjee are mentioned.
Chapter 7 Pharmacopoeias in Colonial Times gives a
historical account of the London Pharmacopoeia with
three Hindustani translations of 1824, 1843 and
1845. There follows a description of Bengal
Dispensatory (1841) and Bengal Pharmacopoeia (1844),
both works of W.B.O’Shaughnessy. Next the
forgotten–even in India–Pharmacopoeia of India
(1868) prepared by Edward John Waring which gave
special attention to indigenous Indian remedies and
its Supplement (1869) are described. In 1900, the
process of making Indian and Colonial Addendum to
British Pharmacopoeia of 1898 also started. The
Addendum was incorporated into British Pharmacopoeia
of 1914 that became recognised as first complete
“Imperial Pharmacopoeia”. A latent movement for the
national Indian pharmacopoeia succeeded in providing
the Indian Pharmacopoeial List 1946. An Indian
Pharmaceutical Codex appeared in 1953. A complete
description of the British Pharmacopoeias
(1864-1945) is also given
Chapter 8 gives information and background of Drugs
Enquiry Committee (1930-31) appointed by Government
of India to study the trade of drugs in Indian
market. Lt. Col. R.N. Chopra was appointed Chairman
of the Committee. Its history-making report in 1931
made cogent recommendations which paved the way for
drugs and pharmacy legislations, pharmacopoeial
publications and development of pharmacy profession
in the country.
Chapter 9
is a short review of the Health Survey and
Development Committee appointed by the Government of
India in 1943 to make a broad survey of the existing
position in regard to health conditions and to make
recommendations for future developments.
Chapter 10 is a narration of the historical
perspective of Drugs and Pharmacy Statutes
pertaining primarily to development in India. For
the sake of comparison attention is also drawn to
the scene in Britain of the time when India was
their colony. Described here is British Pharmacy
Legislations (1852-1933); Drugs Statutes in Britain
(1875-1928); Indian Drug Legislation; Anderson
Report (1937); Import of Drugs Bill (1937); Drugs
Act (1940). After independence Pharmacy Act (1948);
Drugs and Magic Remedies (Objectionable
Advertisements) Act (1954); Drugs and Cosmetics Act
(1947) and Narcotic Drugs and Psychotropic
Substances Act (1985) were introduced.
Chapter 11 explains Pharmacopoeias and Formularies
and the influence of British Pharmacopoeia of 1948
and 1953 in the preparation of first Pharmacopoeia
of India (The Indian Pharmacopoeia) 1955. Their
follows descriptions of Indian Pharmacopoeias of
1966, 1985, 1996, 2007 and the National Formulary of
India that appeared in 1968 and was revised in 1966
and 1979. The composition of various Indian
Pharmacopoeial Committees and functions of India
Pharmacopoeia Commission is given.
Chapter 12 PC1 and Education for Pharmacy Practice
gives a detailed account of the role of Pharmacy
Council of India (PCI), constituted under Pharmacy
Council Act 1948, in making regulations called
Education Regulations prescribing the minimum
standard of education required for qualification as
pharmacist.
Chapter 13 titled Baccalaureate Educations portrays
a composite picture of the historical and
contemporary pharmaceutical instruction, expanding
upon the historical perspective of issues pertaining
to pharmaceutical education. Profiles of older and
new pharmaceutical institutions and numerous
portrait photographs are chronicled. Surveys of
changing patterns in the course of study and
curricula are also presented.
Chapter 14 narrates the development of Postgraduate
Studies and Research in India. History of various
institutions imparting Masters and Doctoral degrees
in pharmacy is given. Reports of various Committees
(Thacker, Nayudamma) for admission to postgraduate
studies and its course of study are also mentioned.
Doctoral studies, research and recognitions in
Indian institutions are as well covered. A brief
description of National Intuitions of Pharmaceutical
Education and Research (NIPER) in Mohali (Punjab) is
also given.
Chapter 15 deals with AICTE and Pharmaceutical
Education. After independence pharmaceutical
education in general got drawn into the ambit of All
India Council of Technical Education (AICTE). A
survey of pertinent developments in this context is
the subject of this chapter.
Chapter 16 Pharmacy Faculties covers the history of
creation of pharmacy faculties in the country.
Chapter 17 illustrates the code of Pharmacy Ethics.
With the advent of Pharmacy Act 1948, slowly the
pharmacy practice started taking shape as a
profession. The prerequisites for one’s entry into
the profession and necessary registration for the
purpose were defined. The pharmacy ethics are
covered in its entirety of how the thought came up,
got developed, adopted including the recent
happenings.
Chapter 18 gives the development of Hospital
Pharmacy in India, its forerunners, and
tribulations, the struggles etc. The development of
properly organised hospital pharmacy and its
management, the role played by pharmacists who
worked in hospitals like M/s S.H. Merchant, Dr B.D.
Miglani, V.K. Osterling, J.S. Walia, K.K. Kaistha
and Miss N.S. Gayatonde is notably recorded. The
recent developments in concept of Clinical Pharmacy
Practice; Drug Information Centre and Didactics are
also appropriately covered.
Chapter 19 gives the description of Retail and
Community Pharmacy. The pharmacy profession started
getting systematised only in the post-colonial era.
The contributions of S.N. Biswas and A. Raptakos are
mentioned. Also covered are Trade Related Issues;
Dispensing, Retailing and Community Care; Over the
Counter Drugs; Pharmacist as Health Educator; Role
in Family Planning Programmes and Professional
Emblem.
Chapter 20 Rural Pharmacy aptly records the dilemmas
related to delivery of health care at rural levels
adequately in a vast and a diverse country like
India, and seemingly simplistic solutions
recommended at different time periods.
Chapter 21 covers the history of Pharmaceutical
Industry under the subtitles: Colonial Drug Industry
and Related Developments; Towards Building of a
Formidable Base on the Country becoming Independent
and Domestic Self-sufficiency and Making to a
Globally Competitive Status. The roles of some
pioneers of pharmaceutical industry like Ray, Gajjar,
Kotibhaskar, Amin, Cooper and Hamied are mentioned.
List of 25 top pharmaceutical companies in India is
also mentioned.
Chapter 22 covers the Biographies of pharmaceutical
professionals of yore who contributed to pharmacy
education, pharmaceutical profession and industrial
developments in India both during the colonial
period and after the independence of the country.
Prof. M.L. Schroff (to whom 2011this book is
dedicated) laid the foundation of pharmacy education
at Banaras Hindu University (BHU) in 1932. N.K. Basu,
D.N. Majumdar, G.P. Srivastava and S. Prasad were
other prominent educationists of BHU. R.P. Patel and
M.L. Khorna also contributed to pharmacy education
and pharmacy profession in general. K.C. Chatterjee,
H.R. Nanji and B.V. Patel played a great role in the
development of industry, statutory control of drugs
and pharmacy practice. S.N. Biswas, J.C. Ghosh and
B.N. Vyas were other prominent pharmacy professional
of the last century. Several medico pharmaceutical
professionals like R.N. Chopra, K.S. Grewal and B.
Mukerji have contributed a lot to the pharmaceutical
developments in India.
Prof. Singh has done a great service to the
profession of pharmacy by writing this book. The
book is excellently written and it is a treasure for
the pharmacy profession, not only in India but for
the pharmacy world. Pharmacy profession in Western
countries means practice in community and
institutional pharmacies. A pharmaceutical history
book covering various aspects of pharmacy
disciplines has been written for the first time. The
author has explored in various chapters the
developments of pharmacy practice in India covering
over 150 years of history and thus provided a
valuable informative data on this subject. The
author has further given a brilliant account of the
British Indian pharmacopoeial history and thus made
a new original addition to the subject of history of
pharmacopoeias. The development of pharmacy
education in a large country like India was a
complex process and the author puts it together into
a clear understandable essay. Biographies of persons
who helped in the development of pharmacy profession
in the country makes the book interesting to read.
Numerous pictures of pharmacies, pharmacopoeias,
institutions and portrait photographs sprinkled
throughout the book help break up the text. An
appendix of the supplementary readings at the end of
the book gives a complete bibliographical list of
the publications of the author. The cover picture of
the book shows the front view of the University
Institute of Pharmaceutical Sciences, Panjab
University, Chandigarh. This book should serve as a
standard text book in the Indian Universities and a
reference on the subject of history of Indian
pharmacy. Prof. Singh has produced an excellent
record of the pharmaceutical history of India and
the subject pharmacy in general, which could be a
valuable resource for understanding one of the most
important professional fields in India today.
Book
Reviewed By: Dr Ravindernath Kaul, Germany
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Title |
:
Life – An Odyssey
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Author |
:
Dr. Manish Maladkar
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Pages |
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168 |
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Price |
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Rs.150/- |
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Publishers |
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Pustak Mahal |
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Under the
title of Life – An Odyssey: Time Tested Mantras
Providing Solutions to Life’s Problems, the author
has compiled selective 35 mussing which throws light
on the hurdles in the journey of human life and the
ways to brings about happiness from these hurdles in
ourselves and spreading it to others. Incorporation
of heart touching short stories and beautiful quotes
makes this literature more interesting and worth
reading.
This book encompasses the deep desire of
completeness within the soul, which drives a man
from the seen to the unseen, to philosophy and
ultimately to the divine. This book is intended for
those capable of knowing their own good. As a
thinker, the author just wishes to awaken the reader
to his own self. We receive from life not what we
want, but what we need. So it is with wisdom that,
it requires wisdom to understand wisdom. That
inherent wisdom, ‘Life-An Odyssey’ intends to touch,
an effort to affect eternity.
The author quotes Buddha’s view on life’s journey:
Faith is nourishment, Virtuous deeds are a shelter,
Wisdom is the light by day and Right mindfulness is
the protection by night. If a man lives a pure life,
nothing can destroy him. If he has conquered greed,
nothing can limit his freedom. Life is a mystery for
those who keep on running behind their expectations,
ignoring the need of exploring their soul and
happiness therein. The changing culture of an
individual and the society towards unhealthy social
environment makes it necessary to find the right
path for the journey of life. The idea behind Life –
An Odyssey is to explore the different aspects of
life, which everybody experiences in their
day-to-day living, though of importance, these are
largely ignored due to our so called ‘busy
schedules’.
Life-An Odyssey: Time-tested Mantras Providing
Solutions to Life’s Problems arouses the dormant
conscience buried deep within each person due to our
hectic lifestyles. Hence, this book can be a pocket
guide for students, and professionals who would love
to bring stability into their lives in this
fast-paced world.
Book Reviewed by: T. N. Bazaz
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Title |
:
Textbook of Biopharmaceutics and
Pharmacokinetics – Concepts and Applications
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Author |
:
C.V.S. Subrahmanyam
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Pages |
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592 |
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Price |
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Rs.300/-(Local), Rs.315/-(Outstation)
and Rs.420/-(Overseas) |
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Publishers |
:
Vallabh Prakashan, Delhi - 110 033 |
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The
science and technology associated with pharmacy has
progressed immensely over the last few decades.
Significant advances have been made in understanding
the pathophysiology of the disease. This has
necessitated the need to optimize the drug therapy.
The aim of the drug formulator is to develop dosage
forms that ensures optimum amount of drug reaches
the target site; at an optimal rate and its
concentration is maintained throughout the entire
duration of therapy. Therefore, it is essential that
we understand the fate of drug after its
administration; the rate processes to which it is
subjected in the body and its behavior after
biotransformation. The twin disciplines of
Biopharmaceutics and Pharmacokinetics have,
therefore, been developed with the objective of
learning how drugs can be utilized optimally in the
treatment of diseases–through design and development
of new and better therapeutic moieties, new dosage
forms and appropriate dosage regimens.
This book consists of 15 chapters. The chapter on
Absorption of Drugs has been dealt with
comprehensively as most of its principles also form
the basis of drug distribution and elimination.
Elaborate treatment of text on Biotransformation of
Drugs in chapter 5 is justified since a pharmacy
student is well versed with the basic chemistry and
enzymology. A brief mention about Bioactivation and
Tissue Toxicity has been included at the end of this
chapter so that after understanding the mechanisms
of drug metabolism, a student will be better placed
to appreciate their significance. Prodrugs discussed
in chapter 6 give insight into the manner in which
chemical formulation techniques can be utilized to
overcome some of the inherent biopharmaceutic and
pharmacokinetic problems of the active principles.
Mathematical treatment of chapters on
pharmacokinetics has been kept to at modest level in
order not to overburden the students with the
complexities of equations and formulae.
A brief description of methods usually employed to
enhance the bioavailability of a drug from its
formulation has been included at the end of chapter
12. In addition to covering various aspects of
design of dosage regimens and application of
pharmacokinetic principles in clinical situations,
the text contains a final chapter on Controlled
Release Medication to familiarize the students with
the principles involved in the design of innovative
formulations.
Though several books are available on the subject,
the material in most of them is presented in a
diffused form or is highly specialized and
discernible to those proficient in the field. The
textbook presents the information in a lucid,
condensed and cohesive form, to cater specifically
the needs of undergraduate and graduate students of
pharmacy.
Book Reviewed by: Raman Sehgal, Associate
Editor, The Pharma Review, New Delhi, India (MSc;
Pharmacology, All India Institute of Medical
Sciences).
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Title |
:
Optimization in Drug Concepts – InVitro
Methods
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Author |
:
Zhengyin Yan and Gary Caldwell
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Pages |
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418 |
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Publishers |
:
Humana Press |
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Recent
analysis of drug attrition rate shows that a
significant number of potential drug candidates fail
in the later stages of clinical development either
due to faulty ADME or due to systemic toxicity /
safety issues. Lead optimization in drug discovery
thus plays an important role in attempting to
uncover the defects in so called drug candidates.
The book Optimization in Drug Concepts – InVitro
Methods is compilation of detailed experimental
protocols necessary for assaying compounds under
evaluation. The book has 25 chapters and each
chapter is contributed by subject matter expert and
covers a wide spectrum of topics that include
physiochemical properties, drug absorption, plasma
protein binding, metabolism, drug toxicity and drug
interactions. Chapter 1 provides experimental
methods measuring fundamental physiochemical
properties (pka solubility and lipophilicity).
CACO-2 model is described in Chapter 2. Chapter 3
covers PAMPA (parallel artificial membrane
permeability) in detail. The perfused rat intestinal
model, which is considered as a gold standard for
evaluation of drug absorption is outlined in Chapter
4.
Chapters 5 and 6 discusses about screening compounds
targeting CNS disease and anti cancer molecules
respectively. Chapter 7 outlines a different
approach to investigate the involvement of drug
transporters using oocytes injected with cRNAs.
Chapters 8 and 9 present several different methods
evaluating plasma protein binding, which include
equilibrium dialysis, ultrafiltration and isothermal
titration calorimetry. The metabolic stability of
drug candidates can be determined from in vitro
incubations with either hepatocytes or microsomes as
described in Chapter 10.
Chapter 11 outlines methods for identifying
oxidative metabolites using microsomes or S9
fractions. Chapter 12 describes a general approach
identifying UGTs responsible for metabolizing a
given drug candidate. CYP induction using human
hepatocytes is described in Chapter 13.
Chapter 14 describes a high throughput approach
screening for 13 individual CYPs by using
fluorescent substrates and cDNA-expresed enzymes,
and Chapter 15 presents a traditional method
assessing the inhibition of those major CYPs in
human liver microsomes. A systematic approach is
given in Chapter 16 to identify mechanism –based CYP
inhibitors.
In Chapter 17, detection of DNA adducts is described
using 32P-postlabeling combining with PAGE or HPLC
radioactive analysis; analysis of CYP-mediagted
covalent DNA adducts is presented in Chapter 18.
Two methods detecting DNA damage at the level of
individual eukaryotes induced by xenobiotics are
provided including a traditional COMET (Chapter 19)
and a rapid cell-based reporter system (Chapter 20).
Although the Ames test has long been used to detect
mutagens and possible carcinogens, an improved
version assay given in Chapter 21 significantly
reduces background resulting from contamination in
S9 fractions. Also a modified mouse lymphoma assay
(MLA) is outlined in Chapter 22, because this assay
has been recommended as one of core toxicology
tests.
As QT prolongation caused by interaction of drug
molecules with HERG channels remains to be a common
concern in drug discovery, a high throughput in
vitro assay is devised in Chapter 23 to screen
compounds for interaction with HERG. Reactive
metabolites generated by CYPs can be trapped by the
addition of glutathione to in vitro incubations and
structurally characterized using mass spectrometry
(Chapter 24). The last chapter presents a new in
vitro assay assessing the reactivity of
acylglucuronides (Chapter 25).
Each chapter contains introduction, materials,
methods and notes sections. The introduction
contains important background information. The
materials section lists all the equipment and
reagents necessary to carry out the assay, while
step-by-step protocols are outlines in the methods
section. The book is intended to serve a wide
audience that includes all professionals involved in
drug development.
Book Reviewed by: Raman Sehgal (M.S;
Pharmacology, All India Institute of Medical
Sciences).
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Title |
:
Drug Metabolism - Current Concepts
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Author |
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Cornia Ionescu and Mino R. Caira
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Pages |
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420 |
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Publishers |
:
Springer India Pvt. Ltd. |
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The book
Drug Metabolism - Current Concepts is intended to
serve a wide audience that includes undergraduate
and postgraduate students of pharmacy, pharmacology,
medicine, biochemistry, chemistry and related fields
as well as other healthcare professionals and
medicinal chemists.
In the first chapter, the principles underlying drug
absorption, distribution, metabolism and elimination
are described in detail. Chapter 2 and 3 deals with
the chemistry of the biotransformation reactions and
includes both Phase 1 and Phase 2 reactions. Further
details of the structural features, mechanism of
action in biotransformation and enzyme regulation
appear in Chapter 4. Enzyme induction, enzyme
inhibition with special reference to Cytochrome P450
enzyme system is explained meticulously in chapter
5. This is followed, in Chapter 6, by a discussion
of the factors affecting drug biotransformation. The
authors have discussed influences of age, sex,
hormonal status, diseased state. An introduction to
relatively new discipline of Pharmacogenetics,
probing the effect of gene variability on drug
biotransformation is discussed in Chapter 7. This
chapter covers implications of genetic variations
for future drug dispensing. Chapter 8 discusses two
important topics that have significant clinical
implications namely drug interactions and adverse
drug reactions. Finally chapter 9 attempts to
demonstrate how principles of drug metabolism can be
incorporated into the drug designing process to
maximize the therapeutic efficacy of the molecule.
This can be of paramount interest to the medicinal
chemist for designing safe and efficacious
candidates.
The text is supported extensively throughout by
pertinent example to illustrate the principles and a
special effort has been made to to include
literature references of the recent studies and
reviews which very well justifies the term ‘current’
in the title of this work.
Book Reviewed by: Raman Sehgal (M.Sc;
Pharmacology, All India Institute of Medical
Sciences).
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Title |
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A Textbook of Pharmacy Practice
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Author |
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K. G. Revikumar and B. D. Miglani
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Price |
:
Paperback Rs. 450 and Hardbound Rs.750
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Pages |
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554 |
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Publishers |
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Career Publications, Nashik |
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The origin
of the medical education in India is attributable
almost entirely to Indian Medical Service (IMS).
Close to the independence of the country (1947),
there were 19 colleges granting medical degrees.
Every care was taken to put the Western system of
medicine on strong footing, however, no serious
government effort was made to produce pharmaceutical
manpower of adequate quantity. There were chemists
and druggists’ class run in medical colleges in
Madras and Vishakapatnam, this being the only course
in colonial India that was geared to provide
qualified manpower for pharmacy practice. The course
was run along with the lines of instructions
imparted by Pharmaceutical Society of Great Britain.
There was also a class of “compounders”, who were
low-level practitioners of pharmacy and in some
places the term dispenser was used for them. They
had no formalized training until the process of
education started in Bengal in 1881. The compounders
were ill-paid and disparaged as professionals. In
colonial days, the drugs and related items required
to sustain the new medical systems had to be
imported from overseas; the drug industry of India
was at a rudimentary stage. Big pharmacy houses
emerged that were generally managed by British
pharmacists. Their customers were by and large
Europeans. Many other chemists’ shops run by Indians
sprang up for common man who could not afford higher
prices. They were run by unqualified personals.
Government hospitals did not have organised hospital
pharmacies. The lowly paid compounders were engaged
for dispensing and those who styled themselves as
chemists and druggists were not formally trained.
The apothecaries and hospital assistants had
medico-pharmaceutical functions. As compared to
Western countries like USA, England, Germany,
pharmacy practice in India was in a very
underdeveloped state. There was a desperate shortage
of professional pharmacists. Such was India’s
pharmaceutical inheritance from the colonial era.
The Pharmacy Act of 1948 finally provided for the
regulation and practice of pharmacy. The Pharmacy
Council of India was constituted for the purpose of
correcting the deplorable situation regarding the
pharmacy practice.
Since 1960s, the Indian Hospital Pharmacists
Association and its official mouthpiece, the Indian
Journal of Hospital Pharmacy struggled hard to
popularise and develop the hospital pharmacy,
clinical pharmacy , community pharmacy and pharmacy
practice in general. The efforts and the tireless
devotion of Dr. B.D.Miglani are highly commendable
and praiseworthy. He lectured on the subject of
hospital pharmacy endlessly in many conferences in
India and started M.Pharm course in hospital
pharmacy in Delhi University in 1982. The
introduction of subjects like hospital pharmacy,
clinical pharmacy and community pharmacy in the
B.Pharm curriculum (in 1980s), then starting of
M.Pharm pharmacy practice course in a number of
institutions during the latter part of 1990s and in
the subsequent years and introduction of Pharm. D in
2008 are considered as milestones in the development
and popularisation of pharmacy practice in India.
Till now not much reading material was available on
pharmacy practice for the undergraduate and graduate
students in India. The publication of this book “A
Textbook of Pharmacy Practice” by Revikumar and
Miglani is a great enrichment to the subject of
pharmacy practice. A complete book devoted to all
the aspects of pharmacy practice has been published
in India for the first time. The book is divided in
12 Chapters: (1)Hospitals (2) Hospital Pharmacy (3)
Community Pharmacy Services (4) Clinical Pharmacy
(5) Medical Errors (6) Pharmacovigilance and Adverse
Drug Reactions (7) Procurement, Storage, Inventory
Control and Distribution of Medicines (8) Patient
Counselling and Patient Compliance (9)
Pharmacoepidemiology (10) Pharmacoeconomics and
Quality of Life (11) Principles and Concepts of
Research in Health Science and Pharmacy Practice
(12) Professional Ethics in Pharmacy Practice.
Each Chapter is divided in subtitles and enriched
with required, relevant and related information from
the perspective of a pharmacy practice student. The
authors have tried to link the various aspects of
the hospital and clinical pharmacy into a reasonably
coherent text. While writing this book and
discussing the relevant and related issues, the
authors have tried to give sufficient Indian
orientation and wherever needed touched the
situations in other countries so as to make the
reader aware of the global and local situations.
This textbook is well written giving details in each
chapter, which makes the subject more
understandable. Each chapter is supplemented with
tables, illustrations and examples, which gives the
reader clearer review of the text. At the end of
each chapter a list of references is also quoted so
that one gets an additional view of the literature.
A glossary at the end of the book provides an
excellent explanation of the scientific words and
abbreviations used in this book which is an
additional supplement to the knowledge of pharmacy
practice. A few pictures make this book livelier.
This book is a great enrichment to the profession of
pharmacy in general and to pharmacy practice in
particular. It should be recommended to all pharmacy
professionals in the country and should become a
part of the libraries in the pharmaceutical
institutions, pharmaceutical industry, hospitals and
other health institutions. It shall be of particular
use, interest and applications to the pharmacy
degree, postgraduate research, doctor of pharmacy (Pharm.D)
students in India and to the profession of pharmacy.
I am convinced that this book will be accepted by
pharmacy professionals and students as a worthwhile
contribution to the subject pharmacy practice in
India.
Book Reviewed by: Dr. Ravindernath Kaul,
Germany
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Title |
:
"Fundamentals of Clinical Research -
Bridging medicine, statistics and
operations"
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Author |
:
A Bacchieri and G.D. Cioppa
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Pages |
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335 |
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Publishers |
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Career Publications, Nashik, India |
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As India
has been considered a destination point for
off-shoring of clinical trials, clinical research,
more so, the training of man-power has taken a
driver`s seat in pharmaceutical development. A large
number of academies have mushroomed recently for
this purpose. Great many experts are involved in the
training programmes. But only few have the real
flavour of the intricacies of the subject of
clinical research, least the fundamentals of
Clinical Research.
The present book, describes the three basic pillars
of clinical research namely, medicine, statistics
and operations (the logistics of research). The real
issues such as the choice of subjects, treatments,
randomization and blinding, statistical analysis and
inferences are very core to any clinical trial. The
distinctive features of biomedical studies are the
study protocol, sample size, characteristics of
patients to be enrolled, treatment choice, reducing
bias, cross-over design, parametric and
non-parametric inferences. The book has indepth
description on drug development process and various
phases of clinical trials. While dealing with the
subject matter, the authors have made a practical
approach, in that they describe with examples and
analyse which would help the beginners in biomedical
research to understand and appreciate the importance
of statistics in clinical research.
The book is divided into twelve chapters and each
chapter is further divided in to several sections
which makes the reader to understand the matter in
an organised fashion.
The authors, one of them being a statistician (AB)
and the other (GDC) is a physician, who come from
diverse background and academic interest make an
invincible `combo` in addressing a very complex
subject of clinical research. They are one of the
few scientists who have prepared numerous regulatory
dossiers for pharmaceutical companies. The book is
well organised and written in a user-friendly
manners which will serve both the students and
faculty of clinical research. It is recommended for
all institutions/academies who are running such
courses. It is also for the first time an Indian
publishers (Career Publications) has the rights to
distribute in India the publications of Springer, a
global approach like the clinical research.
Book Reviewed by:
S.K. Kulkarni, Professor of Pharmacology |
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Title |
:
ELEMENTS OF PHARMACOVIGILANCE
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Author |
:
Raman Sehgal, Dr. Rajat Sethi & Dr. Shobha
Rani R Hiremath
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Price |
:
India 1750/-
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Pages |
:
458 |
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Publishers |
:
KONGPOSH Publications Pvt. Ltd.
kongposhpub@gmail.com |
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India is
now considered a hub for global clinical research.
With increase in number of global clinical studies
being carried out, there is also a need for
developing an equally efficient and strong
Pharmacovigilance system. The molecule undergoing
clinical development has to demonstrate both safety
and efficacy not only in clinical trials, but over a
period of time. After the Vioxx tragedy and other
recent high profile drug withdrawals, there is an
elevated public concern regarding product safety
post marketing. It is thus becoming imperative to
proactively recognize the importance of risk
identification and risk assessment in early in drug
development process.
Pharmacovigilance, the last phase in the drug
development, is critical to the protection of public
health and involves continuous monitoring of the
safe use of medicinal products. It is the science
relating to the detection, assessment, understanding
and prevention of the adverse effects of medicines.
According to the World Health Organization, any
Phamacovigilance programme should improve patient
care and safety, encourage the safe and rational use
of drugs and should assess the risk / benefit ratio.
The book entitled “Elements of Pharmacovigilance”
gives a comprehensive view on various aspects of
Pharmacovigilance. The individual authors have
meticulously discussed some of the newer
perspectives like Pharmacovigilance in Unani
Medicine, dental products, over the counter (OTC)
drugs, vaccines and the current scenario of herbal
drug safety.
It should serve a comprehensive guide for all health
care professionals, researchers, academicians and
regulators. The authors and the publishers are to be
commended for producing an excellent and timely
resource for researchers and practitioners with an
interest in this subject.
Book Reviewed by Dr. Nilima A Kshirsagar
Dr. Nilima
A Kshirsagar, Acting Vice Chancellor, Maharashtra
Univrsity of Health Sciences, Nashik, Dean, ESIC,
PGIMSR, Mumbai Emeritus Professor of Clinical
Pharmacology G. S. Medical College, KEM Hospital
Parel, Mumbai
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Title |
:
SIR RAM NATH CHOPRA - Work, Vision and
Legacy
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Author |
:
Prof. Harkishan Singh
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Price |
:
India 600/-
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Pages |
:
266 |
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Publishers |
:
Vallabh Prakashan
Email:
mail@vallabhprakashan.com |
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History
of Pharmacy in India and Related Aspects, Volume 7
Builders and Awareness Creators of Modern Pharmacy 4
Professor Harkishan Singh chose several years ago to
explore the history of modern pharmacy in India,
covering the span of the last few centuries,
including the pharmaceutical progress in independent
India. He has collected a great deal of historical
material through his travels to different libraries
in India and abroad and through considerable
scholarly correspondence. I have visited his home in
Chandigarh and seen the collection, which occupies
two rooms in the upper floor of his house. In my
opinion, it is the largest collection of literature
on the pharmaceutical history of India under one
roof, and Prof. Singh continues to expand the
collection. With hard work and tireless devotion,
Prof. Singh has contributed significantly to the
field of the “History of Pharmacy in India and
Related Aspects.” His standing as a science
historian has been recognised in his election to the
prestigious Académie International d’Historie de la
Pharmacie. He has published six books so far on this
subject: Volume 1: Pharmacopoeias and Formularies
(1994); Volume 2: Pharmaceutical Education (1998);
Volume 3: Pharmacy Practice (2002); Volume 4:
Builders and Awareness Creators of Modern Pharmacy 1
Mahadeva Lal Schroff and the Making of Modern
Pharmacy (2005); Volume 5: Builders and Awareness
Creators of Modern Pharmacy 2 (2008); Volume 6:
Builders and Awareness Creators of Modern Pharmacy 3
Medico-Pharmaceutical Professionals (2009).
Prof. Singh now presents his latest book in this
series Volume 7: Builders and Awareness Creators of
Modern Pharmacy 4. This monograph is devoted to Sir
Ram Nath Chopra, his work, vision and legacy. In the
earlier Volume 6, the author has described the life
and contributions of R.N.Chopra. Volume 7 is mainly
a compilation, reproducing as in original the
historical addresses delivered and writings on
scientific and professional topics of Chopra. A part
of pioneering research paper on Rauwolfia by Chopra
and his work on drug addiction is reproduced in this
book. An article written by Chopra about problems
and prospects of pharmacology career in India with
his own experiences in life is also reprinted here.
Articles by his disciple Dr. B. Mukerji (to whom
this book is dedicated) on his preceptor’s role as
crusader of pharmacology and promoter of pharmacy as
well as a consolidated list of Chopra’s publications
is also appended in this book. Among the men who
have adorned the Indian medical profession in the
20th century, Sir Ram Nath Chopra occupies the
foremost position. He was pioneer in the study of
indigenous drugs in India and an outstanding
luminary in the field of medical education and
research. He is widely acclaimed as the Father of
Indian Pharmacology. His glory was that of a pioneer
and a crusader blazing the trial in a so far
untrodden field, full of potentialities. Chopra was
elected as a Fellow of practically all the
scientific bodies and educational organisations in
India, including National Academy of Sciences. In
1925, he was elected President of the Medical and
Veterinary Research Section of Indian Science
Congress and again in 1938 the President of the
Physiology Section during the jubilee session. He
was President of Indian Science Congress held in
Patna in 1948.
Prof. Singh has compiled in this book 10 addresses
delivered by Chopra on various occasions at the
scientific Congresses. Chopra lectured on various
subjects and gave expressions to his view and
experiences on the subjects of pharmacology and
related sciences, indigenous drugs, Indian systems
of medicine, pharmaceutical developments and other
varied topics. In his addresses, he referred also to
Drugs Enquiry Committee (1930-31), which he chaired.
The report of this committee made cogent
recommendations, which paved the way for the drugs
and pharmacy legislations, pharmacopoeial
publications and development of the pharmacy
profession. After going through these lectures
delivered by Chopra and his writings, one gets an
impression of his deep knowledge, his vision and the
concepts he presented for the development of the
medical and pharmaceutical profession in India. He
wanted the utilisation of the local resources for
the indigenous production of drugs so as to reach
the masses of India at lower prices and, thus reduce
the cost of treatment of diseases.
The pioneer work done by Chopra and associates on
Rauwolfia serpentine, Benth referred in one chapter
of this book, gained prominence two decades later as
a source of reserpine. In 1933, it was reported by
his group that an alkaloid obtained from the plant
on experimental studies in animals showed central
depressant properties and lowered the blood
pressure.
The works of Chopra on drug addiction and wide
spread abuse of such drugs as opium, cannabis,
cocaine and alcohol which was prevalent in many
parts of India, attracted international attention.
He produced a wealth of material to combat and treat
their deleterious effects, all worth reading
material in this book.
Another chapter in this book volume is the
description by Chopra about the problems and
prospects of pharmacological career in India with
his own experiences in life. He writes about his
studies in England and his work in pharmacology with
Walter E. Dixon, the first Professor of Pharmacology
in the newly established Chair in Cambridge. His
enthusiasm to work on this subject on his return
back to India came after a decade when he got the
first Chair of the Pharmacology in the newly opened
School of Tropical Medicine, Calcutta. His pioneer
work on indigenous drugs and the disease problems in
India which he later carried in Drug Research
laboratory, Jammu are of educative value and worth
reading in this book. Prof. Singh has presented in
appendices I and II, the original writings of
B.Mukerji about Sir Ram Nath Chopra and the growth
and development of pharmacology and pharmacy in
India; all very excellent tutorial material. The
author has also given a complete list of
publications of Chopra (more than 400) in appendix
III, a very impressive record of Chopra’s work.
This volume written by Prof. Singh like others in
the series is rigorously researched and meticulously
referred. This book is very well written and the
lectures and other great works of Chopra are nicely
complied. By reading this book and the lectures of
Chopra, one gets a fairly good impression as how
much problems India faced both in the medical and
pharmaceutical fields in the first half of the 20th
century. The contributions of Chopra and other
builders and awareness creators of modern pharmacy
have created that illumination, the fruits of which
we are enjoying today in the medical and the
pharmaceutical progress of India. This book should
be very much recommended to the pharmaceutical and
drug professional in the universities and the
industries as well as to all the pharmaceutical and
drug authorities in India and abroad. This book
volume also teaches us that the great works and
dreams of Sir Ram Nath Chopra are still to be
realized so as to make India self sufficient in
health sector.
Book Reviewed by Dr. Ravindernath Kaul,
Germany
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Title |
:
HOW TO PRACTICE - GLP
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Author |
:
P.P. Sharma
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Price |
:
India & Nepal - Rs. 1200/-, Other Countries
- US $100
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Pages |
:
415 |
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Publishers |
:
Vandana Publications Pvt. Ltd. LU-56,
Vishakha Enclave, Delhi-110 088 |
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Good
Laboratory Practice (GLP) is a quality system
concerned with the organizational process and
conditions under which non-clinical health and
environmental safety studies are conducted. This
system, which has been evolved by the member
countries of Organization for Economic Co-operation
and Development (OECD), helps to ensure the quality
of data produced by laboratories by harmonizing the
practices and provides international acceptance to
safety data generated in GLP-certified test
facilities.
The book, ‘How to Practice GLP’ authored by Sh. P.
P. Sharma, former Dy. Drugs Controller, Delhi is a
comprehensive volume on different aspects of GLP.
The book starts with a good introduction which talks
about the evolution of GLP. The book has 7 well
written chapters and the author has very
meticulously shared his expertise. In this book the
author has described all concepts, terminologies,
guidelines and different approaches in GLP. Chapter
1 deals with basic concepts in Quality. In Chapter
2, the author talks in detail about inspection and
its planning. Chapter 3 goes deep into the sampling
and sampling plans. Chapter 4 describes an important
area of Statistical Quality control. Chapter 5
explains the quality of analytical methodologies and
analytical method validation. Chapter 6 deals with
concepts in safety planning and management and
bio-safety and related emergency procedures and
Chapter 7 is all about the practice of GLP in
general that also includes premises, personnel,
equipment SOPs etc.
Some of the highlights of the book are:
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Texts
of several GLPs are reproduced including draft
Indian GLP (Schedule L-1), OECD GLP and USFDA
GLP.
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List
of OECD publications on principles of GLP
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“How
to” guidelines for GLP implementation.
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Information on National GLP Compliance
Monitoring Authority.
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Chapters on basic concepts like Quality,
Inspection, Sampling and statistical quality
control (SQC)
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Appendices also include list of hazardous and
toxic chemicals as laid down in the Chemical and
Accidents (Emergency Planning Preparedness and
Response) Rules, 1996 – Schedule I, Text of
Breeding of and Experiments on Animals (Control
and Supervision) Rules, 1998
The
patient will always want to have a drug that is of
good quality, pure, safe and efficacious. The author
has done a commendable job by writing a book on an
area that is so vital to the consumer. He deserves
all appreciation and congratulations. This book will
be useful for professionals involved in drug testing
labs, Quality control, faculty and students of
pharmacy, drug regulatory officers and other
consultants.
Book Reviewed by Raman Sehgal, Associate
Editor, The Pharma Review, New Delhi, India (MSc;
Pharmacology, All India Institute of Medical
Sciences).
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Modern
Dispensing Pharmacy
The
authors of the book entitled “Modern Dispensing
Pharmacy” (3rd Edition) published by Career
Publications, Hyderabad has discussed the subject in
20 chapters (articles) covered in 430 pages and also
contains an appendix. The overall presentation of
the book is very good. Objective of the book is to
preserve the basics of the art of compounding while
adding modern concepts of dispensing pharmacy. In
the revised third edition, book covers development
of pharmacy, role of pharmacist as health care
provider, prescription writing & prescription
handling, art of compounding, concepts of dispensing
pharmacy, compounding & dispensing of different
pharmaceutical dosage forms etc. Wherever required,
pictograms, tables and graphics have been provided
for better understanding of the subject. In addition
to point wise and schematic presentation, the
description of every point is summarized under
Concept Clear, which facilitates the subject
understanding. Though rich by content, the overall
presentation of the book is not quite impressive. At
page 15 and from page 129 to 132, the prescriptions
in boxes are not readable. Figure 18.6 at P. 374 was
shady. Despite these little drawbacks, this book is
expected to be useful for budding pharmacists as
well as educators and practicing pharmacists.
Book reviewed by Mr. R. K. Rishi
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Title |
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CONCEPTS IN CHRONOPHARMACOLOGY
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Author |
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N. Udupa, P.D. Gupta
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Price |
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INR 550.00, $ 80.00, £ 70.00
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Pages |
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183 |
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Publishers |
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Shyam Prakashan
E-mail:
ankit_146@sify.com Website:
www.shyamprakashan.com
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Concepts on Chronopharmacology
Metabolic fate of drug is a function of time. The
importance of 'Chronopharmacology' is now being felt
in almost all branches of pharmaceutical sciences
including drug design, drug development,
bioavailability, efficacy, toxicology and
administration. In Ayurveda, the importance of
circadian rhythm was well recognized since ancient
times and the medicines were prescribed to a patient
with due consideration to time. Recently,
pharmacologists have discovered that drugs when
given with body rhythms showed not only synergistic
effects but also caused fewer side effects. We all
know sleeping pills should be taken at night for
maximum effects.
The book
entitled "Concepts in Chronopharmacolgy" is a well
written book with an aim to impress upon the
importance of 'time' in pharmaceutical sciences. In
Chapter 5 and Chapter 6 the author talks about the
importance of Chronopharmacokinetics and
Chronopharmacodynamics of the drugs. Different
contributing authors have very interestingly
discussed the role of biological clock in Infectious
diseases, human reproduction, cardiovascular
disorders, respiratory disorders, diabetes, cancer,
psychiatric disorders. A chapter each on
Chronotherapy and Chronotoxicology is very
interesting. The seasonal rhythms are very well
exhibited in figures throughout the book. After
reading the book, one can easily conclude the
message given to the readers 'receiving an apt
medication at right form, at right dose and also at
the right TIME'. I would like to congratulate both
the editors and senior researchers Dr. N. Udupa and
Dr. P. D Gupta for bringing out such a wonderful
compilation on a rare but interesting topic.
I sincerely hope it will be very useful to all
pharmaceutical professionals.
Book reviewed by Dr. Rajat Sethi, Assistant
Professor, Texas A &M Health Science Center, College
of Pharmacy, Kingsville, Texas and Raman Sehgal, MS
Pharmacology (AIIMS, India)
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Pharmacognosy and Phytochemistry Volume-I
Pharmacognosy and Phytochemistry - volume 1
book is an updated version of First edition and is
much improved both in qualitative and quantitative
aspects. This book provides deep information and
understanding of the subject Pharmacognosy and
various drugs of Natural origin. The book is divided
into 21 chapters dealing with introduction of
Phannacognosy, its linkage with Pharmaceutical
botany and details of commercial and quality control
aspects of herbals which are well desired these
days. The book provides sufficient knowledge for the
microscopical analysis and processing of crude
drugs. Further, the book has a chapter on Extraction
and isolation of phytoconstituents where the
information is found less sufficient and some latest
isolation and purification techniques can be added
in detail. However, the chapters on Biosynthetic
pathways and elucidation techniques and remaining
chapters on Fixed oils and fats, carbohydrates,
Glycosides, Tannins, volatile oils, Resins,
Alkaloids, Enzymes, Drugs of mineral origin, Natural
fibres are very well written giving the most
relevant information on classification,
biosynthesis, chemical tests, production, quality
control aspects and related individual drugs
details. One chapter on Drugs from marine sources
should also have been included.
The printing and binding of book, presentation of
chapters and design of cover page is very
impressive. Figures, sketches and chemical
structures are suitably and sufficiently
incorporated. Language of the book is simple,
understandable and with comparatively less
topographic mistakes.
Moreover, author of the book, Prof. Vinod D. Rangari,
Principal, J. L. Chaturvedi College of Pharmacy,
Nagpur, has a good reputation in the field of herbal
research. His vast experience in the field of herbal
standardisation has been reflected well in the
presentation of this book which has made it
different from all other text books written on this
subject.
This book will be more useful and will serve as the
text book for the students of undergraduate level.
Students can find sufficient and updated information
on the topics they need in their curriculum. Few
chapters like Commerce and quality control,
Production of crude drugs, General Biosynthetic
pathways and techniques for elucidation
ofbiosynthetic pathways will also be useful for
postgraduate students.
Overall, the book Pharmacognosy and Phytochemistry -
volume 1 is well written with sufficient information
which will be of great use for undergraduate
students of Pharmacy.
Book reviewed by Prof. S.H. Ansari, Dean,
Faculty of Pharmacy, Jamia Hamdard, New Delhi
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Pharmaceutical Science is fast evolving entity and
encompasses diverse fields like anatomy, physiology,
biochemistry, microbiology, botany, chemistry,
formulation, engineering, marketing etc. More
recently, biotechnology too has become an undeniable
part of pharmaceutical industry.
We come across new words on a daily basis and are
frequently in need of a resource that we can refer
in times of need.
The author has very meticulously used his experience
in the pharmaceutical industry and has presented
latest technological terms that are often
encountered today. The author has aptly given more
thrust on current and contemporary knowledge rather
than history and origin of pharmaceutical sciences.
The "Dictionary of Pharmaceuticals and
Biotechnology" would be of immense help to
undergraduate and post graduate students of
pharmacy, biotechnology, medicine, nursing and
allied health sciences. In addition, it will also
serve as a reference material for pharmaceutical and
biotech industry.
I congratulate Dr. Kohli, a senior member of the
Indian pharmaceutical industry for coming out with
an updated dictionary that combines the intertwined
fields of pharmaceuticals and biotechnology.
Dictionary reviewed by: Dr Rajat Sethi
(Assistant Professor, Irma Lerma Rangel College of
Pharmacy, A&M Health Science Center, Texas)
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Title |
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Bioharmaceutics and Pharmacokinetics A
Treatise |
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Author |
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Dr. D. M. Brahmankar and Dr. Sunil B.
Jaiswal |
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Publishers |
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Vallabh Prakashan, E-mail:
mail@vallabhprakashan.com |
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Over a
period of time, pharmaceutical science has evolved
from mere compounding and dispensing of drugs.
Recent advances in understanding disease and genetic
make-up have necessitated the need to optimize and
individualize drug therapy. The concern today is to
produce a dosage form which is not only
pharmaceutically elegant, but releases the drug at
the target site at a desired rate and uniformly
maintains the extent of absorption. Thus, the twin
disciplines of Biopharmaceutics and Pharmacokinetics
play a critical role in drug development.
This textbook "Biopharmaceutics and Pharmacokinetics
– A Treatise" by Dr. Brahmankar and Dr Jaiswal has
15 very well written chapters. The chapter on
Absorption of Drugs has been dealt with
comprehensively as most of its principles also form
the basis of drug distribution and elimination.
Elaborate treatment of text on Biotransformation of
Drugs in Chapter 5 is justified since a pharmacy
student is well versed with the basic chemistry and
enzymology. A brief mention about Bioactivation and
Tissue Toxicity has been included at the end of this
chapter so that after understanding the mechanisms
of drug metabolism, a student will be better placed
to appreciate their significance. Prodrugs discussed
in chapter 6 give insight into the manner in which
chemical formulation techniques can be utilized to
overcome some of the inherent Biopharmaceutics and
pharmacokinetic problems of the active principles.
Mathematical treatment of chapter on
pharmacokinetics has been kept to at modest level in
order not to overburden the students with the
complexities of equations and formulae. A brief
description of methods usually employed to enhance
the bioavailability of a drug from its formulation
has been included at the end of chapter 12. In
addition to covering various aspects of design and
dosage regimens and application of pharmacokinetic
principles in clinical situations, the text contains
a final chapter on Controlled Release Medication to
familiarize the students with the principles
involved in the design of innovative formulations.
The authors have used very simple language for easy
grasp of the subject. Also, simple figures and
tables are liberally used throughout the book for
better understanding. In addition, revision
questions including numericals at the end of each
chapter are designed strategically to complement the
text of the chapter.
The book would be of immense help to B. Pharm, M.
Pharm and PhD students.
I would like to congratulate the authors for an
excellent attempt to address one of the dynamic
areas of drug research.
Book Reviewed by: by Raman Sehgal,
Senior Clinical Research Scientist; ICON Clinical
Research Pvt. Ltd., M.S. (Pharmacology); All India
Institute of Medical Sciences, New Delhi
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Title |
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History of Pharmacy in India and Related
Aspects, Volume 5
Builders and Awareness Creators of Modern Pharmacy 2 |
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Author |
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Prof. Harkishan Singh |
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Publishers |
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Vallabh Prakashan, E-mail:
mail@vallabhprakashan.com |
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As
compared to western countries, we in India are
hardly aware of our history of pharmacy, development
of our institutions and of builders and creators of
these temples of learning. The fact is that not much
literature was available to the pharmacy
professionals in our country. Professor Harkishan
Singh, a prominent medicinal chemist and a
pharmaceutical historian of international repute has
done pioneer work by doing intensive research on the
pharmaceutical history both in pre- and
post-independence period of India. With tremendous
zeal, hard work and tireless devotion, the author
has given birth to a new topic "History of Pharmacy
in India and Related Aspects". He has summarised his
efforts with his archival collections (bound into
more than 1200 volumes) in various monographs:
Volume 1 Pharmacopoeias and Formularies, Volume 2
Pharmaceutical Education, Volume 3 Pharmacy
Practice. These books have revolutionized
understanding the history of pharmacy in India of
last 200 hundred years and given Indian science
valuable documents untraced or unknown so far.
The present progress of pharmacy education,
pharmaceutical profession and industrial
developments in India is the concentrated efforts of
many intellectuals and visionaries of the country.
Prof. Singh has not missed to write the biographies
and achievements of these great men, whom he
describes as "Builders and Awareness Creators of
Modern Pharmacy". In the book History of Pharmacy
and Related Aspects Volume 4, Series1 (2005), he has
published the biography of Mahedeva Lal Schroff, the
father of modern pharmaceutical education in India.
Prof. Schroff laid the foundation of pharmacy
education from 1932 -1943 at Banaras Hindu
University (BHU). Besides this, he took active part
in various pharmaceutical professional bodies in the
Govt. of India and in the pharmaceutical industry as
well as in the promotion of pharmaceutical
journalism.
Prof. Singh has done biographical studies of many
more prominent pharmaceutical luminaries, who worked
tirelessly for the profession of pharmacy in the
country. He has now published Volume 5, Series 2 of
the builders and awareness creators of modern
pharmacy. 12 luminaries have been selected and a
chapter is dedicated to each of them. Each one of
them made significant contributions for organisation
of the profession, development of the pharmaceutical
education and sciences, industry, statutory control
on drugs and pharmacy, pharmacy practice and other
aspects of pharmacy.
The responsibility of guiding the pharmacy
department at BHU was given in 1943 to Nitai Krishna
Basu, who further organised the pharmaceutical
education and laid the firm foundation of the
pharmacy studies in the country. He was assisted in
his mission by three other devoted faculty members,
Dhirendra Nath Majumdar, Gurakh Prasad Srivastava
and Sankatha Prasad. They all worked together to
make BHU the first temple of learning and a place of
pilgrimage for pharmacist. With spirited zeal and
devotion, these four missionaries of Indian pharmacy
continued to serve the cause of education and
profession and stayed in the department till
superannuation. During this period the department of
pharmaceutics at BHU attained the status of world
level institution of pharmaceutical education and
research. The author has written the life and works
of these four great pioneers of pharmacy and
sacrifices they made for the profession in 4
separate chapters. No other person can better
describe their contribution than Prof Singh, since
he himself was a student and a faculty member at
BHU.
The most significant contribution of Ratilal
Prabhudas Patel has been the creation and building
of Lallabhai Motilal College of Pharmacy at
Ahmedabad, the growth and destiny of which he guided
for 17 years. He was professionally very active and
served the cause through the medium of Indian
Pharmaceutical Association and Pharmacy Council of
India. All these constitute an impressive set of
credentials but, in spite of that, he did not get an
appropriate place in the history of Indian pharmacy.
The author has paid rich tributes to him and
mentioned at the end of the chapter, "The name of
this prominent pioneer of pharmacy deserves to be
rehabilitated".
Manohar Lal Khorana was an academician, a complete
pharmaceutical scientist, associated with
professional and statutory bodies. His works and
achievements in promoting pharmacy journalism and
his other contributions to the pharmacy profession
in India are worth reading in this book.
The life works and efforts of Surendra Nath Biswas,
an enlightened Calcutta based chemist and druggist
and a well-read and well-informed professional of
India is briefly but precisely described. Biswas
expressed about the lack of education of chemists
and druggists and formalised education for the
pharmacists. He struggled for upgrading the pharmacy
profession and working conditions of pharmacists in
the country and wrote endlessly on the subject.
Keshab Chandra Chatterjee distinguished himself as a
prominent pharmacy leader. His role in the
pharmaceutical industry and allied aspects,
consolidating the Indian Pharmaceutical Association,
Pharmacy Act and Pharmaceutical Services are highly
recognised. He was an educationist and a man of many
parts.
Homi Ruttonji Nanajee was an educationist, worked in
professional and statutory bodies and contributed to
pharmacy practice and worked in professional forums.
His leading role in drugs control, in drug analysis
as analyst, and promotion of drug industry are well
known and recognised. Prof. Singh has given a
realistic contribution of this great son of pharmacy
in 32 pages with 7 historical pictures.
Bhupendra Vallabhbhai Patel left deep impression in
building modern pharmacy in India. His role in
pioneering the development and consolidation of the
pharmacy profession has been applauded. He graduated
in pharmacy and became an accomplished
pharmacologist. Prof. Singh has described in detail
the role B.V. Patel played in pharmaceutical forums,
statutory bodies and pharmacy practice, structuring
the drugs control and promotion of pharmaceutical
education. He left a deep impact in the building of
modern pharmacy in India. His accomplishments are so
great that the author has dedicated 34 pages on him
in his book.
The contribution of Baij Nath Vyas, a pharmacologist
by profession as the first president of the United
Provinces Pharmaceutical Association and later named
as Indian Pharmaceutical Association are briefly but
well recorded. India lost in him one of the foremost
physicians of the country, first President of Indian
Pharmaceutical Association and its promoter, an
ardent supporter of pharmaceutical education and
profession.
Prof. Singh has dedicated this book to the memory of
Jyotish Chandra Ghosh, "the forgotten and unsung
pioneer of pharmacy" and written one chapter on him.
Very little was known of this man in the pharmacy
history of India and he practically faded away
quickly from the memory of the profession. J.C.Ghosh
made significant contributions toward pharmaceutical
and allied fields. His contributions include the
areas of pharmaceutical and technological education,
indigenous drugs, pharmaceutical and chemical
industry and drugs and pharmaceutical legislations.
The author has made great efforts to trace the life
and works of this man from different archives in
India and abroad and rediscovered this great
luminary of Indian pharmacy.
The author has done great service to the profession
of pharmacy by publishing this volume. The book is
excellently written and it is a treasure for the
pharmacy profession of India. It is a rigorously
researched book volume. Prof. Singh is known to be
very thorough in writing detail and each chapter is
well referenced. In the appendices the speeches of
some luminaries are also recorded, which makes the
reader understand the problems of the pharmacy
professions in the initial years of India's
independence. This book should be very much
recommended to the pharmaceutical and drug
professionals in the universities and the industries
as well as to all the pharmaceutical and drug
authorities in the country. This book also teaches
us that a few great men have made pharmacy in India.
Book Reviewed by: Dr Ravindernath Kaul,
Germany
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Title |
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History of Pharmacy in India and Related
Aspects, Volume 6
Builders and Awareness Creators of Modern
Pharmacy 3 |
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Author |
:
Prof. Harkishan Singh |
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Publishers |
:
Vallabh Prakashan, E-mail:
mail@vallabhprakashan.com |
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Professor
Harkishan Singh has continued his research on
profiling the lives and contributions of the
pharmaceutical luminaries who laid the foundation of
pharmacy education and profession in the country. He
now presents his latest book on History of Pharmacy
in India and Related Aspects Volume 6, Builders and
Awareness Creators of Modern Pharmacy 3 under
subtitle: Medico-Pharmaceutical Professionals.
Several medico-pharmaceutical professionals have
contributed to pharmaceutical developments in India.
Brevet Colonel Sir Ram Nath Chopra and his onetime
associates Professor Khem Singh Grewal and Dr
Bhishnupada Mukerji stand for their direct
involvement in the building of modern pharmacy in
India. Not only did they distinguish themselves as
pharmacologists, their role in making of modern
pharmacy was equally important. Prof. Singh has
profiled the lives and achievements of these
medico-pharmaceutical professionals in this volume
and devoted one chapter to each of them. This book
is dedicated to the memory of Brevet Col. Sir Ram
Nath Chopra, "parent of pharmacology, pioneer of
systematic studies of indigenous drugs, promoter of
Indian systems of medicine and patron of pharmacy".
The major field of Col. Chopra´s research were
general pharmacology, chemotherapy, indigenous
drugs, drug addiction and drug assays. Brevet Col.
Sir Ram Nath Chopra, a legendary
medico-pharmaceutical professional has left behind a
rich legacy. Prof. Singh has paid rich tributes to
this titan of Indian medical sciences.
Professor Khem Singh Grewal was an accomplished
pharmacologist of his time. He had varied research
interests including the study of medicinal plants.
He participated in carrying out comprehensive survey
on incidence of cancer in India. His most
conspicuous pharmaceutical contribution is the
founding of pharmaceutical education at the
University of Panjab, Lahore. A continuum of Lahore
centre is now the famous University Institute of
Pharmaceutical Science, Panjab University,
Chandigarh, which stands as a living memorial to the
pioneering Grewal. The author has highly commended
the sacrifices and achievements of Prof. Khem Singh
Grewal in the development of pharmacy in India
during the difficult pre- and post- independence
period of Punjab.
Dr Bishnupada Mukerji was the builder of the
Biochemical Standardisation Laboratory and the
statutory Central Drugs Laboratory, Calcutta. He
conceptualized the creation of a national institute
of drug research, which led to the establishment of
the Central Drug Research Institute, Lucknow, the
development of which Dr Mukerji guided for a number
of years as the director. Dr Mukerji significantly
helped the developments of pharmacology and there is
no part of the pharmaceutical activity in which he
did not leave an enduring impact. Prof. Singh writes
at the end of the chapter "Looking to his role in
building pharmacology and pharmacy, undeniably Dr
Bishnupada Mukerji stands tall as a
medico-pharmaceutical professional of great merit of
our land.”
This book like the previous volumes in the series is
rigorously researched and meticulously referred. The
chapters are well documented with subtitles
describing the phases of education, academic
achievements and the contributions of these
luminaries in the pharmaceutical developments of
India. Some historical pictures make this book very
interesting to read. In the appendices, important
speeches of B.Mukerjee and R.N. Chopra at various
conferences are well recorded. Unluckily there is no
record of K.S.Grewals`s papers, as most of the
documents seem to have been left behind in Lahore at
the time of partition. This volume book should be a
part of the libraries of pharmaceutical and medical
institutions and should be very much recommended to
the pharmaceutical and medical professionals in
India and abroad. This book is also meant for health
politicians as reference background to understand as
how medical and pharmacy professionals have to work
together to solve the health problems of our masses.
The great contributions of these three
medico-pharmaceutical professional souls and other
builders and awareness creators of modern pharmacy
have created that illumination, the fruits of which
we are enjoying today in the pharmaceutical progress
of India.
Book Reviewed by: Dr Ravindernath Kaul,
Germany
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Title |
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Dispensing Pharmacy |
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Author |
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Mr. R. M. Mehta |
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Price |
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170/- (In Delhi), 177/- (Outside Delhi) |
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238/- (Outside India) |
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Pages |
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375 |
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Publishers |
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Vallabh Prakashan, LU-56, Vishakha Enclave,
Delhi-110 088 |
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Academicians around the world have a professional
obligation to ensure that dispensing chemists /
pharmacy assistants are competent enough in the
areas in which they are working to a minimum
prescribed standard.
Thus, the demand for a simple, standard and a
complete textbook on Dispensing pharmacy for
pharmacy students at diploma / degree level has been
felt for a long time.
This textbook “Dispensing Pharmacy” by R. M. Mehta
has various well written chapters on General
dispensing procedures, labeling of dispensed
products, containers and closures used for various
dosage forms and Posology.
Chapter 7 in the textbook discusses various Solid
dosage forms (Tablets, Capsules, Pills, Lozenges,
Powders etc) in detail. Chapter 8, 9 and 10 deals
with Monophasic (both preparations for internal and
external use) and Biphasic liquid dosage forms
(Suspensions and emulsions).
Chapter on Semi-solid dosage forms (ointments,
pastes, jellies, creams etc) gives an overview of
the method of preparation, differences amongst
various semi solid dosage forms, additives used in
formulation, applications, their merits and demerits
and incorporates formula for some of the official
pharmacopoeial preparations.
Chapter on Ophthalmic and Sterile dosage forms
discusses eye preparations like eye drops, eye
ointments, eye lotions, eye suspensions, essential
characteristics of these dosage forms, types of
parenteral solutions, their formulation etc in
detail. The chapter also enlists the various
sterility tests carried out as per the pharmacopeia.
Also, this book can also serve as a manual for
practical for dispensing pharmacy for both Diploma
and B. Pharma students.
In addition, the chapter on Pharmaceutical
calculations, incompatibilities in prescriptions and
additives is an additional feature of the book.
Following the chapters, the book also incorporates
some useful appendices. Appendix 1 and 2 discusses
the human and veterinary doses of drugs
respectively; their uses and preferred route of
administrations. Appendix 3 of the book contains a
list of references recommended for further reading.
Some of
the salient features of the book include:
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Very
simple language for easy grasp of the subject.
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Vivid
diagrams and illustrations for better
understanding of the subject.
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Revision questions at the end of each chapter.
The book
would be of immense help to undergraduate and post
graduate pharmacy students and related disciplines
of medicine and nursing.
I would like to congratulate the author for an
excellent compilation on Dispensing Pharmacy.
Book Reviewed by: Raman Sehgal, Senior
Clinical Research Scientist; ICON Clinical Research
Pvt. Ltd.
M.S. (Pharmacology); All India Institute of Medical
Sciences, New Delhi
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Title |
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Looking into Living Things... Through MRI |
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Author |
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Dr R S Chaughule, Dr S S Ranade |
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Price |
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1750/- |
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Pages |
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340 pages |
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Publishers |
:
Prism Publications, 15/4, Shivpuri, Near
Chembur Naka, S.T. Road, Chembur,
Mumbai-400 071.E-mail:
ajitn@vsnl.com
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MRI
Spectroscopy was discovered by Felix Bloch (Stanford
University) and Edward Mills Purcell (Harvard
University) way back in 1946. Since the 1980s, MRI
has grown to be an indispensable tool in the medical
diagnosis of many maladies especially of soft
tissue, such as the brain and spine. Its application
to biomedical sciences and subsequently in the field
of life sciences, agriculture, geological sciences,
food technology is noteworthy.
The book “Looking into living things through MRI”
covers a very wide range of systems and phenomena,
and will not only inform the reader about the less
familiar areas, but will suggest new ideas useful in
human medicine.
The chapter on Wood discusses the process of drying
of young wood, giving an account of water movement
from central vascular tissue elements and exit route
by capillary process, resulting in final product
wood. This is immensely readable scientific account
of wood structure as seen by MRI.
The book has well written chapters on applications
of MRI in various fields like food science where the
authors have meticulously described how this
technique can be used in a simple and efficient way
to monitor the quality of apples, citrus fruit and
wine grapes. Other applications discussed in the
book include providing new possibilities of
exploring seafood, meat structure and ripening
process of Iberian Ham by MRI.
Chapter 8 provides an insight into Bread making
process from dough stage to baked product. The
chapter also reviews 'croissants' and 'sandwich'
structure. One is also taken to cellular level of
organization of living things by MR Spectroscopy.
Chapter on MRCP (Magnetic Resonance Cholangio
Pancreatography) shows MRI in clinical scenario;
chapter on new MRI pulse sequences provides research
angle. Likewise, Lithium in mammalian systems
explores possibilities with other magnetic nuclei
amenable to MRI.
Chapter on MR study of implantology illustrates new
application of MRI in the field of dentistry. A
chapter on clinical application of MRI discusses the
use of this technique in oncology, lungs. The
difficulties faced in respect of proton imagine such
as motional artifacts are reduced with the help of
asymmetric imaging and rapid line scan and the study
of lung diseases like pulmonary edema and emphysema
are also presented.
The book also has a well written MRI on
Nanotechnology on which discusses nanomagnetic
probes for bioimaging. The authors have provided
extensive examples, rich bibliography, scans,
illustrations and graphs where ever required.
This is an informative, admirable and much overdue
book that provides insights into diverse life forms.
The book for the first time provides a glimpse of
the clinical and non-clinical applications. I would
like to congratulate the author and the experts for
an excellent compilation.
Book Reviewed by: Dr. Anshu Rohatgi, Senior
Consultant Neurologist, Sir Ganga Ram Hospital, New
Delhi
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Title |
:
Views & Reviews |
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Author |
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Prof. Harkishan Singh |
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Pages |
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628 |
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Publishers |
:
APTI, Bangalore, |
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Tel.: 080-22234619 Fax: 22225834 |
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E-mail:
aptialerts@yahoo.com |
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Last year
when I went to Banaras University campus to attend
the 59th IPC In December 2007, I was most happy to
meet Prof Harkishan Singh " A Mine of Information on
Pharmaceutical Sciences and History". He was
introduced to me by another master of pharmaceutical
education, Dr. B.D. Miglani whom I have known for
many years through our interaction in the journal -
Eastern Pharmacist which closed down some years ago.
The contents of Prof. Harkishan Singh's book Views
and Reviews is a compilation of over 100 articles
which he has written, from the article titled
"Research in Pharmacy" published in Pharma student
(BHU) in 1954 to"Education at Punjab University"
published in the souvenir of the 12th APTI
Convention at Chandigarh in 2007.
These
articles provide you with the story of the rise and
transformation of the Indian Pharma Industry /
Academia in the last 50 years, including the various
associations / Organisations / Committees formed
during this period and where they stand today.
But the best part of this " Mine of Information" are
the chapters dealing with Who's Who's of the
Pharmaceutical Academia in India, pharmacists who
have contributed and helped the industry to reach
where it stands today, an industry of Global
Standing. If not for Prof. Harkishan Singh's
articles on them, most of these stalwarts would have
been forgotten. This well documented book form Prof.
Harkishan Singh must not only find a place in all
Pharmaceutical College libraries in India as well as
abroad but also as a reference book in all other
libraries where people want to know about the India
Pharma Academia.
Book Reviewed by: Mr. Triloki Bazaz,
Consultant, The Pharma Review
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Title |
:
Cosmetics-Formulation, Mfg. & Quality
Control |
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Author |
:
P.P. Sharma |
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Price |
:
India & Nepal - Rs. 2100/-, Other Countries
- US $150 |
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Pages |
:
890 |
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Publishers |
:
Vandana Publications Pvt. Ltd. LU-56,
Vishakha Enclave, Delhi-110 088 |
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Cosmetics
are so extensively used articles that their use
begins with rising from the bed in the morning (e.g.
toothpaste/ toothpowder) till late in the evening
while going to bed (e.g. night creams). This calls
for them to be of good quality. Books help in
improving quality of the products.
The book,
Cosmetics-Formulation, Mfg. & Quality Control
authored by Sh. P. P. Sharma, former Dy. Drugs
Controller, Delhi is a comprehensive volume on
different aspects of cosmetics. Besides introduction
which contains history of development of cosmetics,
the book has eight parts. Part one deals with
regulatory provisions, plant layout for cosmetics
manufacture, theoretical aspects of processes used
in the manufacture of cosmetics, commonly used raw
materials and an important chapter on minimization
of microbial contamination in cosmetics. Part two
deals with cosmetics for skin. Part three deals with
cosmetics for hair. Part four deals with cosmetics
for the eyes. Part five deals with the cosmetics for
the nails. Part six deals with the cosmetics for the
teeth. Part seven deals with miscellaneous cosmetics
like fragrances, aerosols, toilet soaps, baby
cosmetics and now a days sought after
cosmetics-herbal cosmetics. Part eight deals with
quality control of cosmetics. This part is very
important from the point of view of safety of
consumers.
The author
has aptly written chapters giving general
information about a cosmetic category, formulation
considerations including likely characteristics of
finished cosmetics by using ingredients which have
functional uses like moisturizer, emollient,
cleansing etc., general methods of manufacture of
cosmetics and also specific methods of manufacture
if the method has intricacies of chemical reaction
or safety problems. Some of the highlights of the
book are:
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a
chapter on herbal cosmetics including list of
herbs, methods of decoction, extracts flower
waters etc.;
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a
chapter on baby cosmetics; l a chapter on
fragrances including essential oils, synthetic
aromatic chemicals, fixation, compounding,
maturing etc.;
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a
chapter on toilet soap including methods of
manufacture of soaps, characteristics of soaps
and different types of soaps;
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a
chapter on hypoallergenic cosmetics;
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a
chapter on quality control of cosmetics citing
Indian standards for cosmetics;
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a
chapter on stability of cosmetics including
parameters for tests and methodology;
-
appendices listing names of some machinery
manufacturers and trade names of chemicals of
some indigenous and some foreign manufacturers.
The author
has done a commendable job by writing a book on
cosmetics right from plant layout to formulation to
manufacture to quality control and stability
studies. He deserves appreciation and
congratulations. With a wide area of information on
cosmetics, this book will be useful for cosmetic
chemists, faculty and students of pharmacy, drug
regulatory officers and consultants.
Book Reviewed by: Dr. P.D. Sethi, Pharma
Analyst
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Title |
:
Oral Lipid-Based Formulations: Enhancing the
Bioavailability of Poorly Water-Soluble
Drugs |
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Author |
:
David J. Hauss |
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Price |
:
$119.95 (Hardcover) |
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Pages |
:
339 |
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Publishers |
:
Informa Healthcare Inc., New Yourk, NY 10017 |
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Website:
www.informahealthcare.com |
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Oral
delivery of nearly one-half of the drug compounds
gets thwarted owing to their high lipophilicity and
consequently poor aqueous solubility. Oral
bioavailability of such drugs, being function of
their aqueous solubility and dissolution, tends to
exhibit low magnitude and high intra- and
inter-subject variability.
Oral lipid-based drug delivery systems have proved
their immense potential in ameliorating the poor and
inconsistent gastrointestinal absorption of poorly
soluble drugs. Of late, an alarmingly high spurt of
various literature instances and marketed products
of such lipid-based formulations has been witnessed
across the global pharma world. Despite the immense
utilities of the lipid-based drug formulations, only
limited reviews have been published dedicated to
this specialized topic till date. The information on
their diverse vistas lies mostly scattered in
various texts and journals. Accordingly, the maiden
attempt to bring forth the pertinent facts and
figures in the form of an integrated volume is
indeed a commendable and timely endeavor.
Written in lucid style, the book covers myriad
aspects of lipid-based formulations and their usage
in enhancing the bioavailability of poorly
water-soluble drugs. The book has been divided into
various chapters, each encompassing a sizable
account on their design and development, in vitro
characterization, in vivo animal studies, and
eventually, establishment of IVIVC and IVIVR
relationships. Besides, the mechanistic influence of
various lipidic constituents and of such
formulations during fasted and non-fasted states,
and the ultimate fate of lipidic drug products in
gastrointestinal milieu have been explicitly
elaborated. Amongst the diverse types of
self-emulsifying formulations dealt with in the
book, important types include liquid SEDDS and
SMEDDS, lipid-based isotropic solutions and solid
dispersions, hard-capsule formats and supersaturable
SEDDS. The remarkable highlight of this book is its
industrial outlook that exclusively brings forth the
current market status of these lipidic delivery
systems, selection of various GRAS-listed excipients
for their formulation development, and scaling up
the prototype formulations to Phase I/II clinical
trial batches.
Based on the famous adage, “a picture is worth one
thousand words”, a diversity of illustrations have
been immaculately presented as explicative graphs,
photographs, methodology flow charts, apparatus
outlines, tables, bar charts, etc. that make the
book an interesting reading. Each chapter is
adequately referenced to the pertinent and updated
literature. Most book chapters have been contributed
by a galaxy of authors, acclaimed in their
respective domains of pharmaceutical technology,
analytical research, pharmaceutics, process
development, pathology, etc. Special inputs from
industry experts tend to enrich the researchers on
technical know-how of large scale production of such
formulations.
The authors, however, have focused primarily on the
conventional self-emulsifying formulations, missing
due emphasis on the updates like positively-charged
self-emulsifying drug delivery systems (SEDDS),
solid SEDDS and SEDDS of traditional herbal
medicines, ample information on which is currently
available from literature. It would be much more
pragmatic if the newer and expanded edition of the
book covers other relevant precepts like federal
issues and toxicity concerns (especially when the
particle/globule size falls in nano or sub-nano
range), application of DoE optimization of such
lipidic systems, technology for modification of
liquid based systems into solid ones, integration of
these methodologies with controlled release ones,
and work examples on these novel drug delivery
technologies. Another minor peccadillo of the book
is that the authors explain the prevalent global
perspective of these lipid-based formulations taking
instances solely from developed nations representing
various continents like USA, UK and Japan. It would
be more holistic and pragmatic if the current
scenario in the developing nations is also taken
into apt consideration.
In nutshell, as already mentioned, the book is
likely to serve the acute need of the hour. It can
be a pleasure to the product development scientists,
pharmacy students and researchers to familiarize
themselves with the principles and methodology of
lipid-based drug delivery systems. The book can be
an excellent addition to the library shelves of drug
manufacturing houses and pharmaceutical institutes.
Reviewed by: Prof. Bhupinder Singh Bhoop -
University Institute of Pharmaceutical Sciences,
Punjab University
S. Bandyopadhyay - UGC Meritorious Doctoral
Research Fellow (Pharmaceutics), Panjab University,
Chandigarh
E-mail:
bsbhoop@yahoo.com
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Title |
:
Pharmaceutical Packaging Technology |
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Author |
:
U K Jain, D C Goupale, S Nayak |
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Price |
:
Rs. 795/- |
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Pages |
:
279 |
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Publishers |
:
PharmaMed Press |
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E-mail:
info@pharmamedpress.com |
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The
packaging of Pharmaceuticals is as much important as
the medicine or drug, which is being packed. The
quality to any medicine cannot only be imparted by
imparting quality in its contents but it is of
immense importance how this quality is being
protected with continuously changing atmospheric
conditions. Proper packaging is the only way to give
desired shelf-life to pharmaceuticals.
It has been seen that a large number of medicines do
not give the desired therapeutic effect due to
faulty packaging. Packaging technology has become a
separate subject in pharmaceutical sciences due to
its vital applications in preserving therapeutic
efficacy of drugs. Before starting the book writing
on this subject, we noticed that the subject was
less understood and it has been compiled with few
chapters in some books. This inspired us to present
detailed account in the form of a specialized book
on the subject. Also the Packaging Technology has
emerged as separate subject among specialized
subjects of Pharmacy curriculum of almost all
Universities.
Present book comprises of 16 chapters. The starting
page of each chapter consists of chapter summary,
which will help the teachers, students and other
co-readers in revision of contents of whole chapter
in only few minutes. Further the content of each
chapter is arranged to facilitate the effortless
flow of information in simple, motivating, and
commonsensical approach. Detailed physico-chemical
information on raw material e.g., glass, plastic,
polymers, metals etc., used in Pharmaceutical
packaging is presented to facilitate conceptual use
of raw material for a particular type of medicinal
preparation. Since the raw materials are common for
packaging of other products, the scientific
information may further be helpful to allied persons
who deal with any kind of packaging.
A positive effort has been made to cover up all
individual and specialized aspects of Pharmaceutical
packaging sciences. More information is provided on
Pharmaceutical packaging design, based on
characteristic properties of material used in
packaging. Blister and strips packaging are of
growing importance and so a chapter is included on
this topic which would be of great value to our
readers. Parenteral and ophthalmic products need
sterilized packaging; therefore a chapter on
sterilization, covering unique features for
sterilizing packaging materials, has been included.
Because of rising role of European Union as a world
center for Pharmaceutical regulation and because of
the significance of international harmonization of
drug standards, a new chapter on regulatory aspects
of Pharmaceutical packaging has been added. Chapters
on quality control and stability testing of packages
would explain the shelf-life concern aspects of the
active pharmaceutical ingredient (API) packed.
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Title |
:
Builders and Awareness Creators of Modern
Pharmacy |
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Author |
:
Prof. Harkishan Singh |
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Price |
:
Rs. 600/- |
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Pages |
:
362 |
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Publishers |
:
Vallabh Prakashan |
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E-mail:
mail@vallabhprakashan.com |
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This book
of Prof. Harkishan Singh is part 2 of part 1, Volume
4 written by him in the series “History of Pharmacy
and Related Aspects” now designated as “Builders and
Awareness Creators of Modem Pharmacy”. The book is
Volume 5 in the series.
The book for the purpose of review can be broadly
divided in two important sections. Section 1
“Preface, Acknowledgements, Introduction, and
Index”. And Section-2 “Profiles of twelve prominent
pharmaceutical personages of yesteryears detailing
their contributions and lives and presidential
addresses of six of them”. To satisfy
inquisitiveness of readers, it may be pointed out
that Prof. Singh, in part 1, Vol. 4 of the series,
has honored Prof. M.L. Shroff by projecting him as
titan and icon of Modern Pharmacy. He sees him as
the maker of modern pharmacy of India. His profile
does not appear in the volume under review except
reference wherever necessary.
In the acknowledgement the author has expressed his
gratitude to the management of archives and
libraries of institutions in India and abroad,
numbering about one dozen wherefrom he got valuable
data for his write-up. The author also contacted
individuals and organizations numbering nearly four
hundred for same purpose. He has gracefully
acknowledged their cooperation by their mention in
index and text at appropriate places.
In preface and introduction, Prof. Singh gives
reason for deviation in his original plan, namely
concentration on three subject oriented plan to
biographies of prominent individuals who contributed
to building of modern pharmacy in India. In preface
and introduction the author has made mention of
development of western medical systems. As against
this, the author observed that the pharmacy
component remained largely neglected. It is perhaps,
Prof. Singh's this contention that made him change
the title. Maintaining his this line of thought, he
states “unfortunately pharmacy stood neglected
during the British period” that is in
pre-independence era. The profession of pharmacy,
the author states remained in unorganized and very
poor state. The condition according to him was such
that to modernize the profession was an uphill task.
Its solution is also suggested by the author in the
introduction. He states “I had available with me
introductory information on many of the
professionals who had worked for the building and
awareness creation of modern pharmacy, which was a
new discipline for us and it required a lot of
struggle for getting pharmacy accepted as a partner
in the modern health care system”. The way to
tread above referred uphill task, Prof. Singh
mentions the professionals of yore, who gained
prominence during the colonial period and continued
to be professionally active in early decades of
independent India, could be short listed for
profiling”. For this, he had in mind, as could be
seen from mid part of Introduction, two stalwarts
fulfilling such requirement (i) Jyotish Chandra
Ghosh and (ii) Surendra Nath Biswas. In fact,
for his regard and respect, Prof. Singh has
dedicated the book to J.C. Ghosh stating
“Dedicated to the memory of Jyotish Chandra Ghosh,
the forgotten and unsung pioneer of Pharmacy”.
It seems the author had in mind a shortlist of one
dozen stalwarts. For other ten Prof. Singh turned
his attention to pharmaceutical forums through which
these ten stalwarts jointly sow seeds of modern
pharmacy. These seeds broke the ground and the
profession has grown to its present state say
pillars of modern pharmacy. Most of the pioneers had
active professional life ranging from 25 35 years.
In the initial stage, they being from different
disciplines, there was possibility of difference in
their approach. Perhaps in view of this, he has
arranged chapters / titled in their name, in
alphabetical order.
In reference to profiles of twelve pharmaceutical
personages, Prof. Singh states “it is done in a
way that composite personality of each one is
projected properly” This is followed by
presidential address at Pharmaceutical Congress of
six presidents, by way of seven appendices. The
profiles are paragraphed under more or less similar
titles, as early life and background; professional
study and education, choice of discipline;
contribution and achievements etc. Period of
activity is stated wherever it is necessary. As
stated earlier, it ranges between end of colonial
period to early decade of independent India. This
period-a wide spanning period of 19 - 20 years, has
no sharp cut off line i.e. formation of The Drug
Enquiry Committee of 1930 - 31 to enactment of two
important professional legislations viz: Drugs Act
1940 and Pharmacy Act 1948. Former sowing the seeds
of modern pharmacy and later seeds breaking ground
as seedings of modern pharmacy. Former at the foot
of uphill task and the latter at the top of it 'dawn
of modern pharmacy'. Growth and development took
place from these seedings till 1986 when the last
luminary Shri Sanktha Prasad breathed his last a
period of about 40 years. Prof. Harkishan Singh
choice of title for both the volumes is based on
this background.
While some thought of pursuing their professional
activity in the field of education, others preferred
research, quality control, industry etc. There were
some who apart from their field of choice shared
their professional competence by serving as visiting
faculty in teaching institutions, consultants in
industries and likewise. In the earlier years, their
contribution in the field was published in foreign
journals and publications. Later with formation of
forums they got it published in national journals
like Pharma Times; Indian Journal of Pharmacy and
similar other publications of pharmaceutical
associations and organizations. The stalwarts were
however united in the areas like professional
education, growth and development of profession of
pharmacy and importance of forums for common
platforms to achieve such aims and objectives. It is
in view of such approach that we have made
phenomenal progress towards the goal of the modern
pharmacy. It is for this reason, Prof. Singh has
rightly projected the luminaries as “Builders and
Awareness Creators of Modern Pharmacy.”
What is modern or current today would be past by the
next decade. New entrants and beginners in the
profession will have to shoulder the burden of
progress ahead. The profiles provide help and
guidance which can be of immense use to shoulder
such responsibility. The details of text of
appendices can also go a long way in this regard.
The text of addresses gives data of progress made,
difficulties encountered and possible solutions.
Some have forecasted problems and likely
difficulties in progress ahead. They have also
suggested possible solutions, Quality and importance
of details of profiles and addresses can be
appreciated only by going through the details.
The path of growth and development is thorny and
very demanding. Qualitative transformation can be
brought by blending of interest, involvement and
integrity throughout the journey. Contents of the
book provide necessary details and guidance to tread
the path for targeted growth and development.
I extent my heartiest congratulations to the author
Prof. Harkishan Singh for this zealous and untiring
effort to archive the pharmaceutical history of
India in a prolific, precise and lucid manner. I
strongly recommend that educational institutes and
pharma organizations keep this publication in their
library and promote extensive reading. This book can
be a useful orientation programme menu for new
entrants and aspirants to acquaint them with
historical perspective of our profession.
Book Reviewed by Mr. M.R. Shastri, Director
(Retired), Drugs Control Administration, Gujarat
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Title |
:
Foundations In Pharmaceutical Biotechnology |
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Author |
:
B.P. Nagori, Roshan Issarani |
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Price |
:
Rs. 195/- |
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Pages |
:
285 |
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Publishers |
:
Pharma Book Syndicate |
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Tel.: 040-23445666, 23445622 |
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E-mail:
info@pharmabooksyndicate.com
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The field
of Biotechnology, in particular, Pharmaceutical
Biotechnology has evolved very rapidly since the
discovery of INSULIN by Banting and Best in 1922.
Currently, hundred of biotechnology based products
have hit the market and numerous others are in
various phases of clinical development. This
textbook “Foundations in Pharmaceutical
Biotechnology” has various well compiled chapters on
principles of genetic engineering and its
applications, bioinformatics, plant tissue culture,
animal cell / tissue / organ culture, enzyme
immobilization, cell immobilization and their
applications etc. The fundamental concepts in all
the chapters serve as a good foundation to
understand and interpret the latest research and
development going in the field of biotechnology.
Chapter 4 deals with fermentation technology and its
applications in the field of pharmaceutical
biotechnology. Chapter 7 is entirely devoted to
hybridoma technology and discusses various methods
for the production of Monoclonal antibodies. In
chapter 14, covers legal and social issues
concerning the use of biotechnology and a profile of
various regulatory agencies. In addition, the
chapter on halometabolites (halogenated organic
compounds) is quite informative.
In the
end, the authors have added a brief section on
useful websites and a photo gallery which has some
vivid diagrams and illustrations. The book would be
of immense help to undergraduate and post graduate
pharmacy, science and engineering students. We would
like to congratulate the authors for such an
excellent attempt to compile a book on a young
discipline like Pharmaceutical biotechnology that
faces a dearth of quality publications.
Book
reviewed by: Dr. Rajat Sethi, Texas A&M
University, USA and Raman Sehgal, (GVK Biosciences
Pvt. Ltd.) |
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Title |
:
Pharmaceutical and Medicinal Inorganic
Chemistry |
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Author |
:
P. Gundu Rao |
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Price |
:
Rs. 450/- (in Delhi), Rs. 470/- (Outside
Delhi) |
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Pages |
:
486 |
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Publishers |
:
Vallabh Publications |
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Tel.: 011-27342048 |
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E-mail:
mail@vallabhprakashan.com
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Inorganic
Pharmaceutical chemistry has not received adequate
attention over the years even when many inorganic
substances are being used as important medicinal /
diagnostic agents and also serves as pharmaceutical
aids in the pharmaceutical and chemical industry.
This textbook on “Pharmaceutical and Medicinal
Inorganic Chemistry” by Prof. (Dr.) Gundu Rao
consists of 18 well complied chapters. Chapter on
Elements presents the reader with essential facts on
elements which find application in medicine,
analysis including quality control. The chapter on
inorganic toxicology is a welcome addition and
enables the readers to learn about hazards of
improper use of inorganic salts and their possible
treatment by specific antidotes. New approaches in
chapters like Water as a pharmaceutical raw
material, Homeopathic and Veterinary products are
highly appreciated.
The author had very meticulously given information
on various pharmacopeias including the IP, USP,
International Pharmacopeia, British Pharmacopeia and
Japanese Pharmacopeia through which an effort has
been made to introduce some of the basic
characteristics of the expectation from “global
pharmacist”. Newer perspectives have been added to
traditional topics on diagnostic agents,
radiopharmaceuticals and quality control. The
innovative approach in this book would receive ready
acceptance by fellow academicians and students.
Following the chapters, the book also incorporates
various useful appendices. Appendix 1 is a
compilation of commonly used Greek / Latin prefixes
and suffixes. Appendix II is a compilation of
Medical terms used in the text book. Appendix III is
the listing of inorganic pharmaceuticals according
to their application. Appendix IV has important
references and it also has a novel section on
websites consulted by the authors.
The author
has very aptly used his experience and his close
association with the pharmaceutical industry,
regulatory bodies, institutions and other fellow
healthcare professionals and academicians. I would
like to congratulate Prof. Gundu Rao for such an
excellent compilation. The book would be of immense
help to pharmacy student and related disciplines of
medicine, nursing, nutrition, dentistry, etc.
Reviewed by: Dr. P. D. Sethi, Pharmaceutical
Analyst |
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Title |
:
Validation in Pharmaceutical Industry -
Concept, Approaches & guidelines |
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Author |
:
Shri P.P. Sharma |
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Price |
:
India & Nepal Rs. 1200.00 |
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Other Countries |
:
US $ 50.00 |
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Pages |
:
396 |
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Publishers |
:
Vandana Publications Pvt. Ltd. |
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LU-56, Vishakha Enclave, Delhi- 110088. |
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In the
present scenario of Pharmaceuticals industries,
where at every step the analyst has to deal with
regulatory compliance, the book titled “Validation
in Pharmaceutical Industry” Concepts, Approaches &
Guidelines, written by Shri. P. P. Sharma, former Dy.
Drugs Controller, Govt. of NCT of Delhi, will
definitely be a helpful tool for the technocrats
working in the Pharmaceuticals Industries.
In this
book the author has described all concepts,
terminologies, guidelines and different approaches
for validation: The book is divided in eleven
different chapters. Chapter-1 deals with principles
& terminology used in validation. In Chapter 2,
definition, concept & options of validation has been
defined. Chapter 3 goes deep into the Validation
Master Plan (VMP), validation protocol & reports.
Chapter 4 describes, organizational structure for
validation process. Chapter 5 explains the
qualification of premises and validation of HV AC
System. Chapter 6 defines the validation of
utilities. Chapter 7 & 8 deal with cleaning
validation and process validation respectively.
Chapter 9 is entirely devoted to validation of some
special processes i.e. Aseptic and Lyophilization
processes. In Chapter 10, analytical method
validation is defined in detail, covering all
parameters of validation as per USP & ICH guidelines
and Chapter 11 is devoted to computer system
validation.
I would
like to congratulate Shri. P. P .Sharma for such
excellent attempt to compile this unique book. The
book would be helpful for analysts, production
chemist/managers and pharmacy students. I would like
to convey my appreciation and best regards to the
Author.
About
the Author: Shri P. P. Sharma is a well known
authority in the pharmaceutical field. He is a
M.Pharm. (Gold Medallist) from Punjab University and
former Deputy. Drugs Controller & Licensing
authority; Drugs Control Department, Govt. of N.C.T.
Delhi. He was awarded “Best Drug Control Officer
Award” at the IPC in 2004. He is a member of the
Pharmacy Council of India (PCI) and Chairman, Law
Committee, PC I. Shri P. P .Sharma has authored many
books in pharmaceuticals fields like. How to
practice GMPs, How to practice GLP and cosmetic
Formulations, Mfg. & Quality Control.
Book
Reviewed by Dr. R.A. Singh, Director Technical,
Arbro Pharmaceuticals Ltd. New Delhi. Member Indian
Pharmacopoeia Commission Committee. (IPC) |
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