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THE PHARMA REVIEW
(SEPTEMBER – OCTOBER 2020) |
Preclinical Screening and
Animal Models of Human Disease: A Decisive Step for
Clinical Study
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Ms.
Swarnima Negi1 & Dr. Sachdev Yadav2 |
Introduction: Preclinical screening and animal
models are classical pharmacological models used as a
mandatory element in preclinical (toxicological and
pharmacological) studies of new drugs. The approaches
using experimental animals are characterized by
relatively high relevance and the data from the animal
models are extrapolated to humans. A number of
pharmacological models have proven relevance, such as
streptozocin-induced diabetes in mice, digoxin-induced
arrhythmias, experimental autoimmune encephalomyelitis -
a model of multiple sclerosis, asthma, collagen-induced
arthritis, and epilepsy induced by chemical agents or
electric shock. In recent years, the replacement of
animal testing and animal models with in-vitro models
has been increasingly introduced into practice, but some
studies still remain compulsory according to the modern
manuals of pharmaco-toxicological preclinical study.
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